4-Chloro-5-methoxy-2-(pyridin-4-yl)pyrimidine CAS 133661-38-8
| CAS No. | 133661-38-8 |
| Molecular Formula | C10H8ClN3O |
| Molecular Weight | 221.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-Chloro-5-methoxy-2-(pyridin-4-yl)pyrimidine (CAS 133661-38-8) is a high-purity analytical reference standard with the molecular formula C10H8ClN3O and a molecular weight of 221.64 g/mol.
Based on its molecular formula C10H8ClN3O, 4-Chloro-5-methoxy-2-(pyridin-4-yl)pyrimidine contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 221.64 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN3O |
| Molecular Weight | 221.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 1-(2-Chlorobenzyl)-1H-pyrrole-2,5-dione (CAS 133517-61-0)
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- 3-[4-(Trifluoromethyl)phenoxy]benzoic Acid (CAS 72178-29-1)
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- 2-(4-Fluorophenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione (CAS 1257641-06-7)
- Arbidol impurity 44 (CAS CATO-C4X-112944)
- Citalopram-d (CAS 1309283-28-0)
- Palbociclib Impurity 73 (CAS 571188-82-4)
- Potassium (E)-3-bromo-1,4-dichlorobut-2-en-2-yltrifluoroborate (CAS 1692895-64-9)
- 5,6-difluorobenzo[d]oxazol-2(3H)-one (CAS 871367-13-4)
- Methyl 2-3-4-6-tetra-O-benzyl-D-galactopyranoside (CAS 195827-82-8)
- Semaglutide impurity 256 (CAS CATO-C4X-2226256)
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