Valnemulin EP Impurity B CAS 133787-61-8
| CAS No. | 133787-61-8 |
| Molecular Formula | C26H43NO4S |
| Molecular Weight | 465.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Valnemulin EP Impurity B (CAS 133787-61-8, C26H43NO4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Valnemulin EP Impurity B (C26H43NO4S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H43NO4S |
| Molecular Weight | 465.69 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Valnemulin Standards
- Valnemulin (CAS 101312-92-9)
- Valnemulin EP Impurity A (Mixture of Diastereomers) (CAS 1624614-06-7)
- Valnemulin impurity 5 (CAS CATO-C4X-19995)
- Valnemulin impurity 7 (CAS 1350636-92-8)
- Valnemulin impurity 6 (CAS CATO-C4X-19996)
- Valnemulin EP Impurity C (CAS CATO-C4X-19993)
- Valnemulin Trifluoroacetic Acid Salt-d6 (CAS 1217627-44-5)
- Valnemulin Hydrochloride (CAS 133868-46-9)
Recommended Standards
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