N-Methyltetrahydrofolic Acid CAS 134-35-0
| CAS No. | 134-35-0 |
| Molecular Formula | C20H25N7O6 |
| Molecular Weight | 459.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-Methyltetrahydrofolic Acid (CAS 134-35-0), molecular formula C20H25N7O6 and molecular weight 459.46 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-Methyltetrahydrofolic Acid (C20H25N7O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures N-Methyltetrahydrofolic Acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H25N7O6 |
| Molecular Weight | 459.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 7 |
Related N Standards
Recommended Standards
- Levomefolic Acid (CAS 31690-09-2)
- Mivebresib, 98% (HPLC) (CAS 1445993-26-9)
- (6R)-5-Methyl-Tetrahydrofolic Acid (CAS 31690-08-1)
- Methyl 2-(N-(4-((4,6-dimethoxypyrimidin-2-yl)oxy)-2-methylphenyl)sulfamoyl)benzoate (CAS 866154-87-2)
- (3-Bromo-2-methyl-phenyl)-methyl-carbamic acid tert-butyl ester (CAS 1187928-37-5)
- 2-(trifluoromethyl)thiophene-3-carboxylic acid (CAS 767337-58-6)
- (E)-N'-(5-bromopyridin-2-yl)-N,N-dimethylformimidamide (CAS 138888-98-9)
- tert-butyl N-[5-(hydroxyimino)-5,6,7,8-tetrahydronaphthalen-2-yl]carbamate (CAS 1807938-03-9)
- 2-(2-(Piperidin-4-ylidene)propyl)isoindoline-1,3-dione (CAS 849701-08-2)
- 2,5-Bis(2-butyloctyl)-3,6-bis(5-(trimethylstannyl)thiophen-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (CAS 2102299-80-7)
- (2E)-2-[2-(3,5-dimethylphenyl)-2-oxoethylidene]-1,3-thiazolidin-4-one (CAS 744242-03-3)
- 1-Methoxy-3-propylbenzene (CAS 62103-69-9)
- N-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)benzamide (CAS 769951-33-9)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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