1-Chloro-3-ethynyl-2-fluorobenzene CAS 1341512-63-7
| CAS No. | 1341512-63-7 |
| Molecular Formula | C8H4ClF |
| Molecular Weight | 154.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Chloro-3-ethynyl-2-fluorobenzene.
1-Chloro-3-ethynyl-2-fluorobenzene (CAS 1341512-63-7), molecular formula C8H4ClF and molecular weight 154.57 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to fluorine/chlorine substitution, an aromatic ring system, 1-Chloro-3-ethynyl-2-fluorobenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 154.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF |
| Molecular Weight | 154.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-1-ethynyl-4-fluorobenzene (CAS 1057670-02-6)
- 2-Chloro-4-ethynyl-1-fluorobenzene (CAS 1057670-04-8)
- 1-Chloro-2-ethynyl-4-fluorobenzene (CAS 1233501-58-0)
- 1-Chloro-3-ethynyl-5-fluorobenzene (CAS 1233506-04-1)
- 1-Chloro-2-ethynyl-3-fluorobenzene (CAS 1416266-74-4)
- 4-Chloro-1-ethynyl-2-fluorobenzene (CAS 188472-71-1)
- 1-Chloro-4-ethynyl-2-fluorobenzene (CAS 756895-72-4)
- 2-Chloro-1-ethynyl-3-fluorobenzene (CAS 2003928-77-4)
Recommended Standards
- 1-(Chloroethynyl)-4-fluorobenzene (CAS 1737-34-4)
- (Chloromethyl)diethylphosphine oxide (CAS 37016-54-9)
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- Semaglutide Impurity 128 (CAS 2490269-78-6)
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