N-(4-fluoro-3-methylphenyl)tetrahydro-2H-thiopyran-4-amine CAS 1341997-68-9
| CAS No. | 1341997-68-9 |
| Molecular Formula | C12H16FNS |
| Molecular Weight | 225.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(4-fluoro-3-methylphenyl)tetrahydro-2H-thiopyran-4-amine (CAS 1341997-68-9), molecular formula C12H16FNS and molecular weight 225.33 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(4-fluoro-3-methylphenyl)tetrahydro-2H-thiopyran-4-amine (C12H16FNS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), N-(4-fluoro-3-methylphenyl)tetrahydro-2H-thiopyran-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16FNS |
| Molecular Weight | 225.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related N Standards
- n-(2-Fluoro-4-methylphenyl)tetrahydro-2h-thiopyran-4-amine (CAS 1153292-02-4)
- n-(2-Fluoro-5-methylphenyl)tetrahydro-2h-thiopyran-4-amine (CAS 1153292-23-9)
- n-(4-Fluoro-2-methylphenyl)tetrahydro-2h-thiopyran-4-amine (CAS 1156600-39-3)
- n-(5-Fluoro-2-methylphenyl)tetrahydro-2h-thiopyran-4-amine (CAS 1156987-67-5)
- n-(3-Fluoro-4-methylphenyl)tetrahydro-2h-thiopyran-4-amine (CAS 1156987-88-0)
- N-(3-fluoro-2-methylphenyl)tetrahydro-2H-thiopyran-4-amine (CAS 1249339-83-0)
- n-(3-Fluoro-2-methylphenyl)tetrahydro-2h-thiopyran-3-amine (CAS 1339596-41-6)
- n-(4-Fluoro-2-methylphenyl)tetrahydro-2h-thiopyran-3-amine (CAS 1341897-43-5)
Recommended Standards
- N-(5-fluoro-2-methylphenyl)tetrahydro-2H-thiopyran-3-amine (CAS 1342044-81-8)
- n-(3-Fluoro-4-methylphenyl)tetrahydro-2h-thiopyran-3-amine (CAS 1342698-13-8)
- 4-((4-Fluorophenyl)thio)cyclohexan-1-amine (CAS 1339539-72-8)
- n-(2-Fluoro-4-methylphenyl)tetrahydro-2h-thiopyran-3-amine (CAS 1343088-56-1)
- (2-((4-Chloro-2-nitrophenyl)amino)phenyl)(4-methylpiperazin-1-yl)methanone (CAS 65514-72-9)
- 2',5'-Difluoro-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261973-28-7)
- tert-Butyl 5-methyl-1H-pyrazole-1-carboxylate (CAS 1001096-26-9)
- Mutant EGFR inhibitor (CAS 1421373-62-7)
- 5-Amino-N-methyl-2-(1H-pyrazol-1-yl)benzamide (CAS 1420792-56-8)
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- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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