Ethyl 3-(pyrazin-2-yl)-1H-1,2,4-triazole-5-carboxylate CAS 1344335-45-0
| CAS No. | 1344335-45-0 |
| Molecular Formula | C9H9N5O2 |
| Molecular Weight | 219.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 3-(pyrazin-2-yl)-1H-1,2,4-triazole-5-carboxylate (CAS 1344335-45-0) is a high-purity analytical reference standard with the molecular formula C9H9N5O2 and a molecular weight of 219.20 g/mol.
Ethyl 3-(pyrazin-2-yl)-1H-1,2,4-triazole-5-carboxylate (C9H9N5O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9N5O2 |
| Molecular Weight | 219.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 5 |
Related Ethyl Standards
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- 2-Methyl-1-(3-(pyrazin-2-yl)-1H-1,2,4-triazol-5-yl)propan-1-amine (CAS 1707586-60-4)
- Ethyl 3-(pyrazin-2-yl)-1,2,4-oxadiazole-5-carboxylate (CAS 1105190-97-3)
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Recommended Standards
- (4-(3,3,3-Trifluoropropoxy)phenyl)methanamine (CAS 1344312-27-1)
- 5-Methoxy-1-(pyridin-2-yl)-1H-pyrazole-3-carboxylic acid (CAS 1344692-22-3)
- 2-Methoxy-N-(3,4,5-trifluorobenzyl)ethan-1-amine (CAS 1344116-59-1)
- Ethyl 8-hydroxypyrido[3,2-d]pyrimidine-7-carboxylate (CAS 1352395-77-7)
- 2-Acetyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline (CAS 91133-00-5)
- 2-Chloro-5-nitroisoindoline-1,3-dione (CAS 63571-79-9)
- 4,5-Dimethoxypyridin-2-amine (CAS 1000843-61-7)
- Sonidegib (CAS 956697-53-3)
- 2-(6,7-Dihydro-4H-thieno[3,2-c]pyran-4-yl)acetic acid (CAS 1258639-48-3)
- N-(2-Hydroxyphenyl)pivalamide (CAS 64414-11-5)
- 2,5-Dichloro-3,6-difluorothiophenol (CAS 1263377-08-7)
- Furan-3-ylmethanamine hydrochloride (CAS 131052-43-2)
- Ethyl 3-bromo-2,5-dimethylbenzoate (CAS 1805026-04-3)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
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