5-(2-Chloro-5-fluorophenyl)nicotinic acid CAS 1346692-26-9
| CAS No. | 1346692-26-9 |
| Molecular Formula | C12H7ClFNO2 |
| Molecular Weight | 251.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(2-Chloro-5-fluorophenyl)nicotinic acid (CAS 1346692-26-9), molecular formula C12H7ClFNO2 and molecular weight 251.64 g/mol, is a CATO reference standard with documented purity and traceability.
5-(2-Chloro-5-fluorophenyl)nicotinic acid (C12H7ClFNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 5-(2-Chloro-5-fluorophenyl)nicotinic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H7ClFNO2 |
| Molecular Weight | 251.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-6-(3-fluorophenyl)nicotinic acid (CAS 1033845-06-5)
- 4-Chloro-6-(pyrrolidin-1-yl)-2-(trifluoromethyl)pyrimidine (CAS 1189872-15-8)
- 6-Chloro-3-(4-fluorophenyl)picolinic acid (CAS 1214381-04-0)
- 6-(3-Chloro-5-fluorophenyl)picolinic acid (CAS 1261932-98-2)
- 2-(3-Chloro-4-fluorophenyl)isonicotinic acid (CAS 1261951-49-8)
- 5-(3-Chloro-4-fluorophenyl)nicotinic acid (CAS 1261962-61-1)
- 5-(3-Chloro-5-fluorophenyl)nicotinic acid (CAS 1261964-74-2)
- N-(6-Chloro-4-trifluoromethyl-pyridin-2-yl)-N-eth-(Z)-ylidene-N-methyl-hydrazine (CAS 1311283-95-0)
Recommended Standards
- 5-(5-Chloro-2-fluorophenyl)nicotinic acid (CAS 1346692-09-8)
- 1-Chloro-3-fluoro-5-(4-nitrophenyl)benzene (CAS 1352318-39-8)
- 5-(3-Chloro-2-fluorophenyl)nicotinic acid (CAS 1346692-03-2)
- 2-Chloro-1-fluoro-4-(3-nitrophenyl)benzene (CAS 1355247-49-2)
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