Nicardipine Impurity 32 CAS 134957-01-0
| CAS No. | 134957-01-0 |
| Molecular Formula | C28H30N4O6 |
| Molecular Weight | 518.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicardipine Impurity 32.
As a process- or degradation-related impurity, Nicardipine Impurity 32 (CAS 134957-01-0, C28H30N4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nicardipine Impurity 32 (C28H30N4O6) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nicardipine Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H30N4O6 |
| Molecular Weight | 518.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 4 |
Related Nicardipine Standards
- Nicardipine Impurity 69 (CAS CATO-C4X-171069)
- Nicardipine Impurity 43 (CAS CATO-C4X-171043)
- Nicardipine Impurity 68 (CAS CATO-C4X-171068)
- Nicardipine Impurity 65 (CAS CATO-C4X-171065)
- Nicardipine Impurity 11 (CAS CATO-C4X-171011)
- Nicardipine Impurity 60 (CAS CATO-C4X-171060)
- Nicardipine Impurity 61 (CAS CATO-C4X-171061)
- Nicardipine Impurity 71 (CAS CATO-C4X-171071)
Recommended Standards
- Apixaban Impurity 187 (CAS 1904628-12-1)
- Esmolol Impurity 85 (CAS CATO-C4X-189185)
- Apixaban Impurity 186 (CAS 1904628-11-0)
- Fmoc-Ala-(Dmb)Gly-OH (CAS 1188402-17-6)
- Glutathione Impurity 11 (CAS CATO-C4X-118511)
- Iguratimod impurity 98 (CAS CATO-C4X-182698)
- Eperisone Impurity 4 (CAS 1026-87-5)
- 4-(2,4-Difluorophenyl)-2-hydrazono-2,3-dihydrothiazole (CAS 886495-09-6)
- 2-(2-Chlorobenzyl)-1H-benzimidazole (CAS 213133-88-1)
- 2-Methoxy-4-methylpyrimidin-5-ol (CAS 1369766-62-0)
- 7-chloro-1H-indole-2-carbaldehyde (CAS 53590-65-1)
- Ethyl 2-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-1,6-dihydro-6-oxo-5-pyrimidinecarboxylate (CAS 1065074-31-8)
- 2-(3-(Ethylcarbamoyl)-6-oxopyridazin-1(6H)-yl)acetic acid (CAS 1707734-85-7)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
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