4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene CAS 135-12-6
| CAS No. | 135-12-6 |
| Molecular Formula | C12H7Cl2NO3 |
| Molecular Weight | 284.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene (CAS 135-12-6) is a high-purity analytical reference standard with the molecular formula C12H7Cl2NO3 and a molecular weight of 284.09 g/mol.
4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene (C12H7Cl2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7Cl2NO3 |
| Molecular Weight | 284.09 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-6-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 1708370-79-9)
- 2-chloro-6-(4-chlorophenoxy)pyridine-4-carboxylic acid (CAS 42521-19-7)
- 2-Chloro-N-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-acetamide (CAS 54010-92-3)
- 2-Chloro-n-[3-chloro-4-(difluoromethoxy)phenyl]propanamide (CAS 851116-08-0)
- 4-Chloro-1-(2-chlorophenoxy)-2-nitrobenzene (CAS 22544-02-1)
- 2-Chloro-N-(3-chloro-4-fluorophenyl)benzamide (CAS 301159-88-6)
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- 3-Chloro-N-(3-chloro-4-fluorophenyl)benzamide (CAS 349128-37-6)
Recommended Standards
- 2-(3,4-Dichlorophenyl)-5-(2-nitrovinyl)furan (CAS 1297536-44-7)
- 6-(3,4-Dichlorophenoxy)pyridine-2-carboxylic acid (CAS 143028-31-3)
- (3-Iodonaphthalen-2-yl)methanol (CAS 129593-44-8)
- 3-(2,6-Dichlorophenyl)-6,7-dihydro-4H-pyrano[3,4-d]isoxazol-4-one (CAS 156496-83-2)
- 3-(Furan-3-yl)-N-(2-hydroxy-2-(thiophen-2-yl)ethyl)acrylamide (CAS 1798981-45-9)
- 9-(2-Chloro-6-fluorobenzyl)-N,N-dimethyl-9H-purin-6-amine (CAS 70091-23-5)
- 2-Bromo-4-chloro-6-fluorobenzoyl chloride (CAS 1805575-89-6)
- n-(3-(Tert-butylamino)-3-oxopropyl)-2-methylcyclopropane-1-carboxamide (CAS 1428022-94-9)
- 4-(Tert-butoxy)cyclohexan-1-amine (CAS 951625-97-1)
- 3,6-Dichloro-2-methoxybenzoyl chloride (CAS 10411-85-5)
- 3-{[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfamoyl}benzoic acid (CAS 1184252-63-8)
- Riluzole Impurity 7 (CAS 1456696-94-8)
- 4-(4-Ethylthiophenyl)-1-buten-4-ol (CAS 842123-80-2)
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