3-Chloro-6-(4H-1,2,4-triazol-4-yl)picolinic acid CAS 1351392-52-3
| CAS No. | 1351392-52-3 |
| Molecular Formula | C8H5ClN4O2 |
| Molecular Weight | 224.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloro-6-(4H-1,2,4-triazol-4-yl)picolinic acid.
CATO supplies 3-Chloro-6-(4H-1,2,4-triazol-4-yl)picolinic acid (CAS 1351392-52-3), a certified reference material (molecular formula C8H5ClN4O2, MW 224.60 g/mol) for analytical method development and quality control.
3-Chloro-6-(4H-1,2,4-triazol-4-yl)picolinic acid (C8H5ClN4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClN4O2 |
| Molecular Weight | 224.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 1-(2-Chloro-6-nitrophenyl)-1H-1,2,4-triazole (CAS 1018053-08-1)
- 6-Chloro-3-nitroquinolin-4-ol (CAS 101861-61-4)
- 8-Chloro-2-oxo-2H-chromene-3-carboxylic acid (CAS 107747-67-1)
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- [(3-chloro-4-cyanophenyl)carbamoyl]formic acid (CAS 1153559-74-0)
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- 2-Chloro-6-nitroquinazolin-4-amine (CAS 1279870-95-9)
- 2-Chloro-3-nitroquinolin-4-ol (CAS 1314946-36-5)
Recommended Standards
- 5-Chloro-2-(4H-1,2,4-triazol-4-yl)isonicotinic acid (CAS 1351393-59-3)
- 8-Chloro-2-oxo-2H-chromene-4-carboxylic acid (CAS 1355193-80-4)
- 5-(3-Chlorophenyl)-1,2,4-oxadiazole-3-carboxylic acid (CAS 1260774-15-9)
- 2-(6-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetic acid (CAS 1361116-12-2)
- 2-(1H-1,2,3,4-Tetrazol-1-yl)ethane-1-sulfonamide (CAS 1697255-05-2)
- 4-(5-Chloro-3-fluoropyridin-2-yl)morpholine (CAS 1020253-17-1)
- tert-Butyl ((3R)-2-oxoazepan-3-yl)carbamate (CAS 106691-72-9)
- 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (CAS 67165-56-4)
- 6-Amino-5,6,7,8-tetrahydronaphthalene-2,3-diol (CAS 53463-78-8)
- 2-(Ethylthio)-4-methylquinoline (CAS 817166-24-8)
- N'-[6-Chloro-4-(trifluoromethyl)pyridin-2-yl]-4-nitrobenzohydrazide (CAS 1597781-26-4)
- 132587-60-1 Bruceanic acid C 3,10-Ethano-1H,8H-furo(3,4-d)(1)benzopyran-9-acetic acid, 8-acetyl-4-((4-(acetyloxy)-3,4-dimethyl-1-oxo-2-pentenyl)oxy)octahydro-11,12-dihydroxy-3-(methoxycarbonyl)-9-methyl-5-oxo-, (3S-(3alpha,3aalpha,4alpha(E),6aalpha,8alpha,9beta,10alpha,10aS*,11S*,12R*))- (CAS 132587-60-1)
- Lactitol EP Impurity B (CAS 53796-37-5)
- Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS 1139691-72-7)
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