Rifaximin Impurity B CAS 1351775-03-5
| CAS No. | 1351775-03-5 |
| Molecular Formula | C43H49N3O11 |
| Molecular Weight | 783.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 783.86 g/mol gives Rifaximin Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Rifaximin Impurity B (CAS 1351775-03-5, C43H49N3O11) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Rifaximin Impurity B (C43H49N3O11) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C43H49N3O11 |
| Molecular Weight | 783.86 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 3 |
Related Rifaximin Standards
- Rifaximin EP Impurity G (CAS 80621-76-7)
- Rifaximin (CAS 80621-81-4)
- Rifaximin Impurity 12 (CAS CATO-C4X-150512)
- Rifaximin-d6(Major) (CAS 1262992-43-7)
- Rifaximin EP Impurity D (CAS CATO-C4X-15054)
- Rifaximin EP Impurity H (CAS 1210022-90-4)
- Rifaximin EP Impurity B (CAS 13929-35-6)
- Rifaximin EP Impurity F (CAS 14487-05-9)
Recommended Standards
- Cefpodoxime Proxetil Impurity 25 (CAS CATO-C4X-157925)
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- Mal-PEG2-VCP-NB (CAS 2395887-69-9)
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- 6-Carboxyfluorescein N-succinimidyl ester (CAS 92557-81-8)
- Neuroendocrine Regulatory Peptide-1 (rat) (CAS 954420-51-0)
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