6-(4-Chlorophenyl)-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxamide CAS 1351828-67-5
| CAS No. | 1351828-67-5 |
| Molecular Formula | C12H8ClN5O2 |
| Molecular Weight | 289.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-(4-Chlorophenyl)-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxamide.
6-(4-Chlorophenyl)-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxamide (CAS 1351828-67-5) is a high-purity analytical reference standard with the molecular formula C12H8ClN5O2 and a molecular weight of 289.68 g/mol.
The molecular framework of 6-(4-Chlorophenyl)-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxamide (C12H8ClN5O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-(4-Chlorophenyl)-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClN5O2 |
| Molecular Weight | 289.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Chlorophenyl Standards
- 5-(4-Chlorophenyl)-N-(1H-1,2,4-triazol-5-yl)oxazole-2-carboxamide (CAS 1795413-01-2)
- 2-(3-Chlorophenyl)-6-nitro-1H-benzo[d]imidazol-1-ol (CAS 303148-97-2)
- 1-(3-Chlorophenyl)-n-(diethoxyphosphorylmethyl)methanimine (CAS 1132709-92-2)
- 2-(2-((3-Chlorophenyl)carbamoyl)phenyl)acetic acid (CAS 38370-63-7)
- 2-(N-(2-Chlorophenyl)benzamido)acetic acid (CAS 60241-98-7)
- 2-[2-(4-Chlorophenyl)-2-oxoethoxy]benzamide (CAS 501942-41-2)
- n-(4-Chlorophenyl)-2-(4-formylphenoxy)acetamide (CAS 88951-63-7)
- 2-((3-(3-Chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)oxy)ethan-1-amine (CAS 1204296-29-6)
Recommended Standards
- 3-((4-Chloro-2-(trifluoromethyl)phenyl)amino)cyclohex-2-en-1-one (CAS 1217863-05-2)
- Efavirenz Aminoalcohol (CAS 154598-58-0)
- 3-{[2-Chloro-5-(trifluoromethyl)phenyl]-amino}cyclohex-2-en-1-one (CAS 1217862-41-3)
- 2-Amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)benzenemethanol (CAS 168834-43-3)
- 5-Hexanoyl-2,2-dimethylcyclopentan-1-one (CAS 1540837-58-8)
- N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-fluorobenzamide (CAS 2802-85-9)
- 1-(4-Chlorobenzyl)-1H-pyrrole-3-carboxylic acid (CAS 1522746-04-8)
- Nafamostat Impurity 2 (CAS CATO-C4X-13322)
- 8-Piperazin-1-yl-2h-[1,2,4]triazolo[4,3-a]pyrazin-3-one (CAS 1544881-78-8)
- (S)-iPr-Pyox (CAS 108915-04-4)
- 2-Chlorothiazole (CAS 3034-52-4)
- 7,8-Dihydro-6H-cyclopenta[g]quinoxaline (CAS 518036-16-3)
- 1-(Bromomethyl)-3,5-difluoro-2-methylbenzene (CAS 869721-04-0)
- Peptide Impurity 12 (CAS CATO-CPTD788812)
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