Agomelatine Impurity 22 CAS 1353100-18-1
| CAS No. | 1353100-18-1 |
| Molecular Formula | C13H18NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Agomelatine Impurity 22 (CAS 1353100-18-1), a pharmacopoeial impurity reference standard (molecular formula C13H18NOCl, MW 239.74 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Agomelatine Impurity 22 is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 239.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Agomelatine Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18NO Cl |
| Molecular Weight | 239.74 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Agomelatine Standards
- Agomelatine-D3 (CAS 107389-38-0)
- Agomelatine-d6 (CAS 1079389-42-6)
- Agomelatine-d4 (CAS 1079389-44-8)
- Agomelatine Impurity 33 (CAS 1079774-32-5)
- Agomelatine Hydrochloride (CAS 1176316-99-6)
- Agomelatine Impurity 36 (CAS 127299-26-7)
- Agomelatine Impurity 19 (CAS 1352139-51-5)
- Agomelatine Impurity 18 (CAS 1352303-07-1)
Recommended Standards
- Posaconazole Impurity 143 (CAS 1428118-40-4)
- Tadalafil impurity 128 (CAS CATO-C4X-1087128)
- Formoterol Impurity 120 (CAS CATO-C4X-1525120)
- 2-(4-((3,5-Dimethylpiperidin-1-yl)sulfonyl)benzamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide (CAS 449767-19-5)
- Pregabalin Impurity 116 (CAS 1101167-84-3（free base）)
- 5-(3-Bromophenoxy)pentanoic acid (CAS 87411-39-0)
- 2-(Morpholin-4-yl)-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 95640-21-4)
- 4-Chloro-2-(2-fluorophenyl)quinazoline (CAS 610276-37-4)
- Trifluoro-methanesulfonic acid (1,1-dimethylbutyl)dimethylsilyl ester (CAS 2733915-93-8)
- Neuropeptide S (rat) (CAS 412938-75-1)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com