2-{[4-Chloro-2-(trifluoromethyl)phenoxy]methyl}tetrahydrofuran CAS 1353497-90-1
| CAS No. | 1353497-90-1 |
| Molecular Formula | C12H12ClF3O2 |
| Molecular Weight | 280.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 2-{[4-Chloro-2-(trifluoromethyl)phenoxy]methyl}tetrahydrofuran under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies 2-{[4-Chloro-2-(trifluoromethyl)phenoxy]methyl}tetrahydrofuran (CAS 1353497-90-1), a certified reference material (molecular formula C12H12ClF3O2, MW 280.67 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 2-{[4-Chloro-2-(trifluoromethyl)phenoxy]methyl}tetrahydrofuran is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 280.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H12ClF3O2 |
| Molecular Weight | 280.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-N-(tetrahydro-2-furanylmethyl)-5-(trifluoromethyl)-2-pyridinamine (CAS 1036444-19-5)
- 3-Chloro-2-(piperidin-4-yloxy)-5-(trifluoromethyl)pyridine (CAS 1092352-80-1)
- 2-((5-Chloro-2-methylphenyl)amino)-N-(2,2,2-trifluoroethyl)acetamide (CAS 1197789-11-9)
- 2-((3-Chloro-2-methylphenyl)amino)-N-(2,2,2-trifluoroethyl)acetamide (CAS 1197884-32-4)
- 2-((2-Chloro-4-methylphenyl)amino)-N-(2,2,2-trifluoroethyl)acetamide (CAS 1211184-56-3)
- 2-((3-Chloro-4-methylphenyl)amino)-N-(2,2,2-trifluoroethyl)acetamide (CAS 1211395-84-4)
- 3-Chloro-2-(piperidin-3-yloxy)-5-(trifluoromethyl)pyridine (CAS 1242268-26-3)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-3-ol (CAS 1292498-24-8)
Recommended Standards
- (1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-2-yl)methanol (CAS 1306120-26-2)
- Tert-butyl 4-chloro-3-(trifluoromethyl)benzoate (CAS 1370284-36-8)
- 1-(5-Chloro-2-isobutoxyphenyl)-2,2,2-trifluoroethan-1-one (CAS 1443305-50-7)
- 1-(2-Butoxy-5-chlorophenyl)-2,2,2-trifluoroethan-1-one (CAS 1443307-42-3)
- Xanthosine (CAS 146-80-5)
- 3-Amino-N-(2-ethoxyphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide (CAS 496019-13-7)
- 1-(4-Methoxyphenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 98534-83-9)
- 4-Isopropyl-2-oxazolecarboxylic Acid (CAS 1187172-65-1)
- 1-Benzyl-4-(pyridin-4-yl)piperidine-4-carbonitrile (CAS 751462-82-5)
- 5,7-Dichloro-2-(methylthio)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 1374306-27-0)
- 6-(Methylsulfanyl)-1-phenyl-4-(phenylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 478247-60-8)
- 3-Chloro-1H-pyrazolo[4,3-d]pyrimidin-5-amine (CAS 1935950-46-1)
- 2,4-Dimethoxybenzenesulfonamide (CAS 51770-71-9)
- Semaglutide (CAS 910463-68-2（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com