Methyl (1R,2S,3S,5S)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate CAS 135367-08-7
| CAS No. | 135367-08-7 |
| Molecular Formula | C16H20BrNO2 |
| Molecular Weight | 338.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl (1R,2S,3S,5S)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate.
Methyl (1R,2S,3S,5S)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (CAS 135367-08-7), molecular formula C16H20BrNO2 and molecular weight 338.24 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl (1R,2S,3S,5S)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate (C16H20BrNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl (1R,2S,3S,5S)-3-(4-bromophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H20BrNO2 |
| Molecular Weight | 338.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 5-Bromo-1H-indol-3-yl octanoate (CAS 133950-69-3)
- tert-Butyl (S)-4-Bromo-2-(Boc-amino)butyrate (CAS 163210-89-7)
- (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone (CAS 1314241-44-5)
- 1,3-BIs(1,1-dimethylethyl) 2-(3-bromopropyl)imidodicarbonate (CAS 172846-33-2)
- N-[2-(2,5-Dimethoxyphenyl)ethyl]phthalimide (CAS 64584-26-5)
- 2-((3-(3-Bromophenyl)-1H-1,2,4-triazol-5-yl)thio)-N-(3-chlorophenyl)acetamide (CAS 332127-11-4)
- 4-(Ethylthio)-2-hydroxybutanamide (CAS 98278-23-0)
- Poloxime (CAS 17302-61-3)
- 1-(4-Isopropylphenyl)butane-1,3-dione (CAS 29681-96-7)
- 2-(4-Isopropylbenzoyl)oxazole (CAS 898759-99-4)
- 3-Methyl-1-(2-(methylthio)pyrimidin-4-yl)butan-2-one (CAS 1160105-52-1)
- 1-(3-Methoxy-1,2-thiazol-5-yl)ethan-1-one (CAS 1935654-61-7)
- Benzyl 3-((2-aminoethyl)(ethyl)amino)pyrrolidine-1-carboxylate (CAS 1353976-24-5)
- D-Pro37-Tirzepatide (CAS CATO-CPTD788902)
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