6-(Trifluoromethyl)indole CAS 13544-43-9
| CAS No. | 13544-43-9 |
| Molecular Formula | C9H6F3N |
| Molecular Weight | 185.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-(Trifluoromethyl)indole (CAS 13544-43-9) is a high-purity analytical reference standard with the molecular formula C9H6F3N and a molecular weight of 185.15 g/mol.
The molecular framework of 6-(Trifluoromethyl)indole (C9H6F3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(Trifluoromethyl)indole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H6F3N |
| Molecular Weight | 185.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 2-(Trifluoromethyl)indolizine (CAS 1186194-65-9)
- 3-Methyl-2-(trifluoromethyl)benzonitrile (CAS 1214377-26-0)
- 2-Methyl-6-(trifluoromethyl)benzonitrile (CAS 1214385-32-6)
- 4-(Trifluoromethyl)indole (CAS 128562-95-8)
- 7-(Trifluoromethyl)indole (CAS 172217-02-6)
- 2-(Trifluoromethyl)-benzeneacetonitrile (CAS 3038-47-9)
- 2-Methyl-5-(trifluoromethyl)benzonitrile (CAS 261952-03-8)
- 3-(Trifluoromethyl)-1H-indole (CAS 51310-55-5)
Recommended Standards
- 6-Ethoxy-5-fluoronicotinic acid (CAS 1354225-51-6)
- 2-Amino-3-fluoro-6-methoxybenzoic acid (CAS 1354949-83-9)
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- 2-Amino-5-fluoro-4-methoxybenzoic acid (CAS 1363380-91-9)
- trans-1,2-Di(2-thienyl)ethylene (CAS 13640-78-3)
- 6-Bromo-4-fluorobenzo[b]thiophene-2-carboxylic acid (CAS 826995-57-7)
- 2-(2,3-Dimethylphenyl)oxirane (CAS 1406719-08-1)
- 1-Bromo-4-iodo-2,5-dimethylbenzene (CAS 699119-05-6)
- 6-Chlorobenzo[b]thiophene (CAS 66490-20-8)
- 1-(4-(3,3-Difluorocyclobutyl)phenyl)ethanone (CAS 1546395-07-6)
- 2-(1-(2-pHenylhydrazono)ethyl)aniline (CAS 40754-13-0)
- 4-Allyl-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (CAS 1822562-23-1)
- 5-Bromo-3-fluoro-1-(4-methoxybenzyl)-1H-1,2,4-triazole (CAS 1627507-23-6)
- Hexapeptide-11 (CAS 161258-30-6)
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