3-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid CAS 1355171-48-0
| CAS No. | 1355171-48-0 |
| Molecular Formula | C9H4ClF3N2O2 |
| Molecular Weight | 264.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 3-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (CAS 1355171-48-0), a certified reference material (molecular formula C9H4ClF3N2O2, MW 264.59 g/mol) for analytical method development and quality control.
Structurally, 3-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (C9H4ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 264.59 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H4ClF3N2O2 |
| Molecular Weight | 264.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole (CAS 1182910-54-8)
- 6-Chloro-7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one (CAS 119179-66-7)
- 3-Chloro-8-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid (CAS 1237838-81-1)
- 8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 1823188-42-6)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-1,2,4-triazol-3-ol (CAS 320416-31-7)
- 5-Chloro-6-(trifluoromethyl)-1H-benzo[d]imidazole-2-carboxylic acid (CAS 827042-61-5)
- 6-Chloro-2-(trifluoromethyl)-1H-benzo[d]imidazole-4-carboxylic acid (CAS 2102672-24-0)
- 6-Chloro-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 874830-60-1)
Recommended Standards
- 1-Methyl-3-(trifluoroMethyl)-4-(chloroMethyl)-5-(difluoroMethoxy)-1H-pyrazole (CAS 656825-76-2)
- 4-(3,4,5-Trichlorophenyl)piperidine (CAS 1853217-61-4)
- n-(1-(2,3,4-Trichlorophenyl)ethyl)cyclopropanamine (CAS 1158060-10-6)
- 8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic Acid (CAS 353258-35-2)
- 3,5-Dimethylpyrazole-4-carboxylic Acid (CAS 113808-86-9)
- 4-(3-(2-Bromophenyl)-5-mercapto-4h-1,2,4-triazol-4-yl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3h-pyrazol-3-one (CAS 732287-94-4)
- Methyl 4-amino-5-nitronicotinate (CAS 2091416-92-9)
- Methyl 3,4-dibromo-5-fluorobenzoate (CAS 1160574-59-3)
- 4-Methyl-1,3-oxazinane (CAS 267419-10-3)
- Isobergapten (CAS 482-48-4)
- 1-(1H-Pyrazol-1-yl)prop-2-en-1-one (CAS 62715-95-1)
- 2-Methylamine-4,6-dimethylnicotinamide (CAS 276873-05-3)
- 6-(Trifluoromethyl)pyrazine-2-carbaldehyde (CAS 1197233-06-9)
- (2S)-2-amino-4-(hydroxymethylphosphinyl)butanoyl-L-alanyl-L-alanine (2S)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyryl-L-alanyl-L-alanine 2-Amino-4-(methylphosphino)butyrylalanylalanine 35597-43-4 Antibiotic SF 1293 Bialaphos CHEBI:3088 L-phosphinothricyl-L-alanyl-L-alanine N-{(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoyl}-L-alanyl-L-alanine PTT Phosphinothricylalanylalanine bilanafos gamma-(Hydroxymethylphosphinyl)-L-alpha-aminobutyryl-L-alanyl-L-alanine phosphinothricin tripeptide (CAS 35597-43-4)
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