2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde CAS 1356401-39-2
| CAS No. | 1356401-39-2 |
| Molecular Formula | C13H16BClO3 |
| Molecular Weight | 266.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1356401-39-2), molecular formula C13H16BClO3 and molecular weight 266.53 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (C13H16BClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C13H16BClO3 |
| Molecular Weight | 266.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1112209-14-9)
- 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1112209-32-1)
- 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1112209-36-5)
- 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1132669-91-0)
- 4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1246633-36-2)
- 3-Chloro-2-formylphenylboronic acid pinacol ester (CAS 1352129-62-4)
- 2-Chloro-4-formylphenylboronic acid pinacol ester (CAS 1356642-60-8)
- 3-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1418128-94-5)
Recommended Standards
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl chloride (CAS 1181329-14-5)
- 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (CAS 1426320-86-6)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl chloride (CAS 380499-68-3)
- 1-Chloro-2-fluoro-3,4-bis(trifluoromethyl)benzene (CAS 1099597-43-9)
- Ethyl 3,3-dicyclopropylpropanoate (CAS 1027287-49-5)
- (3,4-Difluorophenyl)(1,2,4-oxadiazol-3-yl)methanamine (CAS 1155532-84-5)
- 2,6-Dimethyl-4-oxo-1,4-dihydropyrimidine-5-carbonitrile (CAS 128199-32-6)
- 3,4-Difluoro-N-(4-((methylthio)methyl)thiazol-2-yl)benzamide (CAS 942009-60-1)
- 4-Amino-1-(3-chlorophenyl)pyrrolidin-2-one (CAS 1114823-57-2)
- 2,2-dimethyloctan-3-one (CAS 5340-64-7)
- 5-Amino-4-hydroxy-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (CAS 1782819-13-9)
- 3-Phenyl-5-[1-(3,4,5-trimethoxybenzoyl)pyrrolidin-2-yl]-1,2,4-oxadiazole (CAS 1787855-63-3)
- 2-(N-Methylaminocarbonyl)-3445-pyridineboronic acid pincol ester (CAS 70352-20-4)
- Semaglutide impurity 58 (CAS CATO-C4X-222658)
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