1,5-Dibromo-3-fluoro-2-methoxy-4-methylbenzene CAS 1357103-67-3
| CAS No. | 1357103-67-3 |
| Molecular Formula | C8H7Br2FO |
| Molecular Weight | 297.95 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1,5-Dibromo-3-fluoro-2-methoxy-4-methylbenzene (CAS 1357103-67-3), molecular formula C8H7Br2FO and molecular weight 297.95 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system, 1,5-Dibromo-3-fluoro-2-methoxy-4-methylbenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 297.95 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7Br2FO |
| Molecular Weight | 297.95 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Br-containing |
Related Dibromo Standards
- 1,5-Dibromo-3-ethoxy-2-fluorobenzene (CAS 1349716-79-5)
- 1,3-Dibromo-2-ethoxy-5-fluorobenzene (CAS 1447671-86-4)
- 1,5-Dibromo-2-ethoxy-3-fluorobenzene (CAS 1803776-18-2)
- 1,2-Dibromo-4-ethoxy-3-fluorobenzene (CAS 1804939-30-7)
- 1,3-Dibromo-5-fluoro-2-(methoxymethyl)benzene (CAS 2379322-17-3)
- 2-(3,5-Dibromo-1H-1,2,4-triazol-1-yl)-N-methylacetamide (CAS 919267-26-8)
- 3-(3,5-Dibromo-1H-1,2,4-triazol-1-yl)propanamide (CAS 933551-28-1)
- Ethyl 3,5-dibromo-1H-pyrazole-4-carboxylate (CAS 1017802-86-6)
Recommended Standards
- 6-Chloro-2-(trichloromethyl)-4H-chromen-4-one (CAS 133406-29-8)
- 1-bromo-3-(2-bromoethoxy)-5-fluorobenzene (CAS 1503274-86-9)
- 2-Bromo-1-(2-bromoethoxy)-4-fluorobenzene (CAS 1016879-06-3)
- 5-Bromo-3-(pyrrolidine-1-carbonyl)phenylboronic acid (CAS 2121514-36-9)
- 2-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)-N-(4-(trifluoromethoxy)phenyl)acetamide (CAS 339099-16-0)
- Cyclohexanamine (2S,3S,4S,5R,6S)-6-((5-bromo-1H-indol-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate (CAS 199326-16-4)
- 3-(2-Chloro-4-fluorobenzyl)-5-(6-methoxynaphthalen-2-yl)-5-methylimidazolidine-2,4-dione (CAS 956782-57-3)
- Tert-butyl 3-hydroxy-3-methyl-[1,3'-biazetidine]-1'-carboxylate (CAS 1257294-14-6)
- (S)-(+)-Etodolac (CAS 87249-11-4)
- Ethyl 3,4-dichloro-5-(difluoromethoxy)benzoate (CAS 1806275-67-1)
- N-(Bis(4-methoxyphenyl)methyl)-6-oxo-2-(pyridazin-3-yl)-1,6-dihydropyrimidine-5-carboxamide (CAS 1187990-87-9)
- (4-(Difluoromethyl)-6-iodo-5-methoxypyridin-2-yl)methanol (CAS 1807000-62-9)
- Prostaglandin Impurity 3 (CAS 64700-71-6)
- Peptide Impurity 70 TFA Salt (CAS CATO-CPTD788570)
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