2-Bromo-4'-chloro-2-fluoroacetophenone CAS 1357624-45-3
| CAS No. | 1357624-45-3 |
| Molecular Formula | C8H5BrClFO |
| Molecular Weight | 251.48 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Bromo-4'-chloro-2-fluoroacetophenone (C8H5BrClFO) contains a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-Bromo-4'-chloro-2-fluoroacetophenone (CAS 1357624-45-3), a certified reference material (molecular formula C8H5BrClFO, MW 251.48 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5BrClFO |
| Molecular Weight | 251.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl/Br-containing |
Related Bromo Standards
- 2-Bromo-5-fluorophenylacetyl chloride (CAS 1028314-61-5)
- 2-(2-Bromo-4-fluorophenyl)acetyl chloride (CAS 1086601-89-9)
- 2-Bromo-1-(3-chloro-5-fluorophenyl)ethanone (CAS 1207973-38-3)
- 1-(4-Bromo-3-fluorophenyl)-2-chloroethan-1-one (CAS 1260857-14-4)
- 1-(2-Bromo-4-chloro-5-fluorophenyl)ethan-1-one (CAS 129825-10-1)
- 5-Bromo-2-fluorophenylacetyl chloride (CAS 1346146-33-5)
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- 1-(4-Bromo-2-fluorophenyl)-2-chloroethan-1-one (CAS 1379358-56-1)
Recommended Standards
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- 3-bromo-2-fluoro-5-methylbenzoyl chloride (CAS 1499840-13-9)
- N-t-butyl-(2,3,4,5-tetraÂmethylÂcycloÂpentadienylÂ)-dimethylÂsilylÂamide (CAS 125542-04-3)
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- 3-[2-(2-Propen-1-yloxy)ethoxy]-propionic acid (CAS 13630-56-3)
- 3-(Isopentyloxy)-4-methylbenzaldehyde (CAS 1443349-02-7)
- N-(4-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-2-phenylacetamide (CAS 351521-31-8)
- 4-Bromo-6-(difluoromethyl)-5-methoxypicolinic acid (CAS 1805247-89-5)
- 5-Ethyl 2-[4-[2-(2-carboxyethoxy)ethyl]-1-piperazinyl]-5-pyrimidinecarboxylate (CAS 2382770-96-7)
- 5-[(Dimethylamino)methyl]-3-methoxy-2(1H)-pyridinone (CAS 174095-90-0)
- Dimethocaine-d4 Hydrochloride (CAS 1346601-45-3)
- Tirzepatide(sodium salt) (CAS 2023788-19-2(free base))
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