3-(5-Chloro-2-fluorophenyl)propanoic acid CAS 135832-52-9
| CAS No. | 135832-52-9 |
| Molecular Formula | C9H8ClFO2 |
| Molecular Weight | 202.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 3-(5-Chloro-2-fluorophenyl)propanoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 202.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
3-(5-Chloro-2-fluorophenyl)propanoic acid (CAS 135832-52-9) is a high-purity analytical reference standard with the molecular formula C9H8ClFO2 and a molecular weight of 202.61 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8ClFO2 |
| Molecular Weight | 202.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
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Recommended Standards
- 5-Chloro-2-fluoro-4-methyl-benzoic acid methyl ester (CAS 1355070-62-0)
- 2-(3-Chloro-4-fluorophenyl)propanoic acid (CAS 1368552-34-4)
- Methyl 4-chloro-5-fluoro-2-methylbenzoate (CAS 1352887-83-2)
- 3-Chloro-5-fluoro-4-methoxy-2-methylbenzaldehyde (CAS 1373920-69-4)
- 4-Bromo-4-phenylbutyrophenone (CAS 111826-07-4)
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- 5-((tert-Butoxycarbonyl)amino)-2-cyclohexylthiazole-4-carboxylic acid (CAS 1270034-48-4)
- 3-Benzyloxy-5-hydroxypyridine (CAS 209328-93-8)
- 4-(2-Trifluoromethylbenzoyl)quinoline (CAS 1706458-22-1)
- Methyl 4-amino-5,6-dihydro-2H-pyran-3-carboxylate (CAS 1542711-49-8)
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- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
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