Fmoc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid CAS 136030-33-6
| CAS No. | 136030-33-6 |
| Molecular Formula | C25H21NO4 |
| Molecular Weight | 399.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fmoc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.
Fmoc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 136030-33-6) is a high-purity analytical reference standard with the molecular formula C25H21NO4 and a molecular weight of 399.44 g/mol.
The molecular framework of Fmoc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (C25H21NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Fmoc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H21NO4 |
| Molecular Weight | 399.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 1 |
Related Fmoc Standards
- Fmoc-2-aminoindane-2-carboxylic Acid (CAS 135944-07-9)
- (R)-Fmoc-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (CAS 204317-98-6)
- Fmoc-NH-PEG2-CH2CH2COOH (CAS 872679-70-4)
- Fmoc-trans-3-phenylazetidine-2-carboxylic acid (CAS 204320-45-6)
- N-Fmoc-DL-1-aminoindane-1-carboxylic Acid (CAS 214139-28-3)
- Fmoc-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 130309-33-0)
- FMOC-O-tert-butyl-L-serine-<SUP>13</SUP>C<SUB>3</SUB>,<SUP>15</SUP>N (CAS 1217448-78-6)
- Fmoc-Cys(tBu)-OH (CAS 67436-13-9)
Recommended Standards
- Peptide Impurity 05 (CAS 2322924-83-2)
- Z-p-carboxy-Phe(OtBu)-OH (CAS 270567-85-6)
- N-(3-Cyanophenyl)-2-((2-(3,4-dihydroisoquinolin-2(1H)-yl)-6-methylpyrimidin-4-yl)oxy)acetamide (CAS 1251669-99-4)
- H-Pro-His-Phe-OH (CAS 83960-34-3)
- 1-(Benzo[d][1,3]dioxol-5-yl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (CAS 1097050-86-6)
- 3-(Amino(carboxy)methyl)benzoic acid (CAS 2196-57-8)
- 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol (CAS 27298-75-5)
- Ethyl 2-chloro-4-methylbenzoate (CAS 99500-35-3)
- 5-Nitropyridin-2-amine (CAS 67476-67-9)
- (3-Bromo-2-isobutoxyphenyl)methanamine hydrochloride (CAS 2206265-79-2)
- 1-(Mesitylsulfonyl)-4-(piperidin-1-ylsulfonyl)piperazine (CAS 825607-77-0)
- Fmoc-<SC>D</SC>-beta-homoproline (CAS 193693-61-7)
- Elobixibat Impurity 6 (CAS CATO-C4X-28386)
- Semaglutide impurity 32 (CAS CATO-C4X-222632)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com