7'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one CAS 1360931-90-3
| CAS No. | 1360931-90-3 |
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one (CAS 1360931-90-3) is a high-purity analytical reference standard with the molecular formula C11H8F3NO and a molecular weight of 227.18 g/mol.
The molecular framework of 7'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one (C11H8F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 1-Methyl-7-(trifluoromethyl)quinolin-4(1H)-one (CAS 108494-53-7)
- (4-(Trifluoromethyl)quinolin-2-yl)methanol (CAS 1116339-56-0)
- 1-Methyl-8-(trifluoromethyl)quinolin-4(1H)-one (CAS 1209284-64-9)
- 6-Methyl-2-(trifluoromethyl)quinolin-4(1H)-one (CAS 123638-04-0)
- β-(Trifluoromethyl)-4-morpholinepropanoic acid (CAS 1343857-33-9)
- 1-(6-(Trifluoromethyl)-1H-indol-4-yl)ethanone (CAS 1352897-41-6)
- 5'-(Trifluoromethyl)-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one (CAS 1360898-86-7)
- 1-Methyl-2-(trifluoromethyl)quinolin-4(1H)-one (CAS 139439-36-4)
Recommended Standards
- 1-Methoxy-8-(trifluoromethyl)isoquinoline (CAS 1357945-53-9)
- Methyl (2,2,2-trifluoroacetyl)-L-valinate (CAS 1463-21-4)
- 2,2,2-Trifluoroethyl N-(oxan-4-yl)carbamate (CAS 1479373-40-4)
- n-(Tert-butyl)-n-(2,2,2-trifluoroacetyl)glycine (CAS 1536895-50-7)
- 2-(3-Chloro-4-fluorophenyl)azetidine (CAS 1270582-08-5)
- 8-Methyl-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid (CAS 90771-19-0)
- {4-[((S)-2-Amino-3-methyl-butyryl)-methyl-amino]-cyclohexyl}-carbamic acid benzyl ester (CAS 1354026-91-7)
- 6-Bromopyridine-3-sulfonyl chloride hydrochloride (CAS 1266693-63-3)
- Potassium 8-methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carbodithioate (CAS 1219561-93-9)
- 2-((Isopropylthio)methyl)pyrimidine-4-carboxylic acid (CAS 1484243-09-5)
- Carboxy Primaquine (CAS 77229-68-6)
- 5-(Difluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 1823843-51-1)
- Galanthamine Impurity 34 (CAS CATO-C4X-143534)
- D-allo-Thr7-Semaglutide (CAS CATO-C4X-2226242)
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