5-(3-Fluoro-phenyl)-4-piperidin-3-yl-pyrimidin-2-ylamine dihydrochloride CAS 1361118-68-4
| CAS No. | 1361118-68-4 |
| Molecular Formula | C15H17FN4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 5-(3-Fluoro-phenyl)-4-piperidin-3-yl-pyrimidin-2-ylamine dihydrochloride (CAS 1361118-68-4), a certified reference material (molecular formula C15H17FN4HCl, MW 308.78 g/mol) for analytical method development and quality control.
The molecular framework of 5-(3-Fluoro-phenyl)-4-piperidin-3-yl-pyrimidin-2-ylamine dihydrochloride (C15H17FN4HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C15H17FN4 2*HCl |
| Molecular Weight | 308.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Fluoro Standards
- 4-[(2-Fluoro-4-nitrophenoxy)methyl]-1-methylpiperidine (CAS 1000052-54-9)
- 3-Fluoro-4-((1-methylpiperidin-4-yl)methoxy)aniline (CAS 1000053-56-4)
- 2-Fluoro-5-iodo-4-methoxybenzoic acid (CAS 1000162-78-6)
- Ethyl 4-fluoro-3-ethoxybenzoate (CAS 1000207-63-5)
- 6-fluoro-4-iodo-1H-benzo[d]imidazole (CAS 1000308-33-7)
- 2-Fluoro-3-hydroxybenzonitrile (CAS 1000339-24-1)
- 1-(5-Fluoro-2-methylphenyl)pyrrolidine (CAS 1000339-32-1)
- 3-Fluoro-2-nitrobenzoic Acid (CAS 1000339-51-4)
Recommended Standards
- 1-Allyl-1H-benzo[d]imidazole-2-carbaldehyde (CAS 118482-14-7)
- Ethyl 2-(3-hydroxy-4-nitrophenyl)acetate (CAS 288580-52-9)
- 5-Bromo-2,4-dichlorobenzamide (CAS 1305711-44-7)
- 1-(Bromomethyl)-2-iodo-4,5-dimethoxybenzene (CAS 293732-19-1)
- (4-(Methoxycarbonyl)-1H-indol-2-yl)boronic acid (CAS 2408429-78-5)
- [(3Z)-5-Methyl-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-2,3-dihydro-1H-indol-3-ylidene]amino acetate (CAS 321429-93-0)
- (1R,2S)-methyl 2-hydroxycyclopentanecarboxylate (CAS 122331-02-6)
- (R)-tert-Butyl 3-(3-bromopropyl)piperidine-1-carboxylate (CAS 193629-36-6)
- (R)-3-hydroxytetrahydrofuran-3-carboxylic acid (CAS 111833-89-7)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
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