2-(Aminomethyl)-3-(difluoromethyl)-5-(trifluoromethyl)pyridine-6-acetonitrile CAS 1361732-49-1

Purity 97%+In StockPharmaceutical Standards
CAS No.1361732-49-1
Molecular FormulaC10H8F5N3
Molecular Weight265.18 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-(Aminomethyl)-3-(difluoromethyl)-5-(trifluoromethyl)pyridine-6-acetonitrile CAS 1361732-49-1 chemical structure

Description

The occurrence of 2-(Aminomethyl)-3-(difluoromethyl)-5-(trifluoromethyl)pyridine-6-acetonitrile is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2-(Aminomethyl)-3-(difluoromethyl)-5-(trifluoromethyl)pyridine-6-acetonitrile (CAS 1361732-49-1), molecular formula C10H8F5N3 and molecular weight 265.18 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-(Aminomethyl)-3-(difluoromethyl)-5-(trifluoromethyl)pyridine-6-acetonitrile (C10H8F5N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO manufactures 2-(Aminomethyl)-3-(difluoromethyl)-5-(trifluoromethyl)pyridine-6-acetonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

Molecular FormulaC10H8F5N3
Molecular Weight265.18 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1991
Halogen ContentF-containing
Nitrogen Atoms3

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