2-(4-(Difluoromethyl)-6-methyl-3-(trifluoromethoxy)pyridin-2-yl)acetonitrile CAS 1361776-19-3
| CAS No. | 1361776-19-3 |
| Molecular Formula | C10H7F5N2O |
| Molecular Weight | 266.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-(4-(Difluoromethyl)-6-methyl-3-(trifluoromethoxy)pyridin-2-yl)acetonitrile (CAS 1361776-19-3), a certified reference material (molecular formula C10H7F5N2O, MW 266.17 g/mol) for analytical method development and quality control.
The molecular framework of 2-(4-(Difluoromethyl)-6-methyl-3-(trifluoromethoxy)pyridin-2-yl)acetonitrile (C10H7F5N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(4-(Difluoromethyl)-6-methyl-3-(trifluoromethoxy)pyridin-2-yl)acetonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7F5N2O |
| Molecular Weight | 266.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-6-methyl-5-(trifluoromethoxy)pyridine-3-acetonitrile (CAS 1361776-15-9)
- 2-(Difluoromethyl)-4-methyl-5-(trifluoromethoxy)pyridine-3-acetonitrile (CAS 1361789-92-5)
- 2-(4-(Difluoromethyl)-6-methyl-5-(trifluoromethoxy)pyridin-3-yl)acetonitrile (CAS 1361814-23-4)
- 2-(4-(Difluoromethyl)-3-methyl-5-(trifluoromethoxy)pyridin-2-yl)acetonitrile (CAS 1361814-32-5)
- 2-(4-(Difluoromethyl)-5-methyl-6-(trifluoromethoxy)pyridin-3-yl)acetonitrile (CAS 1361837-45-7)
- 2-(Difluoromethyl)-3-methyl-6-(trifluoromethoxy)pyridine-5-acetonitrile (CAS 1361875-63-9)
- 2-(Difluoromethyl)-6-methyl-3-(trifluoromethoxy)pyridine-4-acetonitrile (CAS 1361904-17-7)
- 2-(4-(Difluoromethyl)-5-methyl-2-(trifluoromethoxy)pyridin-3-yl)acetonitrile (CAS 1361910-10-2)
Recommended Standards
- (4-Chloro-2-methylphenyl)(4-chlorophenyl)methanamine (CAS 1335304-50-1)
- N-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazol-2-amine (CAS 1309981-19-8)
- 4-Methyl-2-(methylthio)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS 1309981-17-6)
- Bis(3-chlorobenzyl)amine (CAS 129041-31-2)
- 5-Methoxy-6-methyl-1H-indazole (CAS 1000343-61-2)
- Methyl spiro[chromane-4,2'-oxirane]-3'-carboxylate (CAS 1496088-82-4)
- 5,6-dimethyl-2,3-dihydropyrazine (CAS 15986-92-2)
- 2-bromo-5-cyanonitrobenzene 3-nitro-4-bromobenzonitrile 4 - Bromo - 3 - nitrobenzonitrile 4-Bromo-3-nitro-benzonitrile 4-bromo-3-nitrobenzonitrile 89642-49-9 benzonitrile, 4-bromo-3-nitro- (CAS 89642-49-9)
- Gramisterol (CAS 1176-52-9)
- 4-Amino-n'-hydroxy-1-methylpiperidine-4-carboximidamide (CAS 1563159-28-3)
- (2S,3S,4S,5R,6R)-2-(iodomethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 7511-38-8)
- Ruthenium tris[μ-[3-(hydroxy-κO)-4-[(4-methyl-1-piperazinyl)methyl]-2(1H)-pyridinonato(2-)-κN1:κO2]]tris[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]tri-cyclo (CAS 835614-52-3)
- tert-Butyl 8-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate (CAS 1453315-97-3)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
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