2-amino-4-chloro-1,3-thiazole-5-carbonitrile CAS 136195-53-4
| CAS No. | 136195-53-4 |
| Molecular Formula | C4H2ClN3S |
| Molecular Weight | 159.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-amino-4-chloro-1,3-thiazole-5-carbonitrile (C4H2ClN3S) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-amino-4-chloro-1,3-thiazole-5-carbonitrile (CAS 136195-53-4) is a high-purity analytical reference standard with the molecular formula C4H2ClN3S and a molecular weight of 159.60 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2ClN3S |
| Molecular Weight | 159.60 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 6-Chloro-2-fluoro-3-methylaniline (CAS 702640-48-0)
- 397E9RKE83 7446-07-3 Tellurium dioxide Tellurium oxide (TeO2) EINECS 231-193-1 Tellurium oxide UNII-397E9RKE83 EC 231-193-1 (CAS 7446-07-3)
- 4-Chloro-3-fluoro-2,6-dimethylpyridine (CAS 3786-95-6)
- 2-(2-(2-Carbamothioylhydrazono)cyclohexyl)isonicotinic acid (CAS 881450-58-4)
- n-Isobutyl-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 339003-69-9)
- 7-Methyl-1,4-dioxaspiro[4.5]dec-7-ene (CAS 83313-55-7)
- D-Carnitine (CAS 541-14-0)
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- Dodecanehydrazide (CAS 5399-22-4)
- 5-Cyclopropyl-4-fluoro-1H-pyrazole-3-carboxylic acid (CAS 681034-74-2)
- Pyrazophos (CAS 13457-18-6)
- 1-(4'-(tert-Butyl)-[1,1'-biphenyl]-4-yl)-2,2,2-trifluoroethanone (CAS 1256482-57-1)
- Palmitoyl Hexapeptide-12 TFA salt (CAS 171263-26-6(Free Base))
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