cis-3-(Boc-amino)-4-(trifluormethyl)piperidine CAS 1363378-20-4
| CAS No. | 1363378-20-4 |
| Molecular Formula | C11H19F3N2O2 |
| Molecular Weight | 268.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of cis-3-(Boc-amino)-4-(trifluormethyl)piperidine (C11H19F3N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
cis-3-(Boc-amino)-4-(trifluormethyl)piperidine (CAS 1363378-20-4) is a high-purity analytical reference standard with the molecular formula C11H19F3N2O2 and a molecular weight of 268.28 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H19F3N2O2 |
| Molecular Weight | 268.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- trans-3-(Boc-amino)-4-(trifluormethyl)piperidine (CAS 1363378-16-8)
- tert-Butyl N-{[(4-fluorophenyl)carbamoyl]methyl}carbamate (CAS 137895-52-4)
- trans-3-(Boc-amino)-5-(trifluormethyl)piperidine (CAS 1363378-12-4)
- tert-Butyl N-{[(3-fluorophenyl)carbamoyl]methyl}carbamate (CAS 1390422-92-0)
- 5-(3-Chloropropyl)-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole (CAS 923809-15-8)
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- 4-(2-tert-Butoxycarbonylamino-ethyl)-benzoic acid methyl ester (CAS 177736-04-8)
- tert-Butyl (trans-4-(((5-iodopyridin-2-yl)(methyl)amino)methyl)cyclohexyl)carbamate (CAS 1313366-19-6)
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- 1-(Boc-amino)-3-(methylamino)propane (CAS 442514-22-9)
- 35746-21-5 (E)-Tetradec-11-enal 11-Tetradecenal, (E)- 11-Tetradecenal, (11E)- AI3-35931 EINECS 252-710-7 (E)-11-Tetradecenal (CAS 35746-21-5)
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