Methyl 4'-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate CAS 1365271-42-6
| CAS No. | 1365271-42-6 |
| Molecular Formula | C15H10F4O2 |
| Molecular Weight | 298.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl 4'-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate (C15H10F4O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Methyl 4'-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate (CAS 1365271-42-6) is a high-purity analytical reference standard with the molecular formula C15H10F4O2 and a molecular weight of 298.23 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 4'-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10F4O2 |
| Molecular Weight | 298.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Methyl Standards
- 2-(3'-Fluoro-4-(trifluoromethyl)biphenyl-3-yl)acetic acid (CAS 1214376-30-3)
- 2-FLuoro-4'-(trifluoromethyl)biphenyl-4-carboxylic acid methyl ester (CAS 1261480-17-4)
- 6-FLuoro-3'-(trifluoromethyl)biphenyl-3-carboxylic acid methyl ester (CAS 1261549-13-6)
- 4-Fluoro-4'-(trifluoromethyl)biphenyl-3-carboxylic acid methyl ester (CAS 1261585-16-3)
- 3-FLuoro-4'-(trifluoromethyl)biphenyl-4-carboxylic acid methyl ester (CAS 1261633-89-9)
- 5-FLuoro-3'-(trifluoromethyl)biphenyl-3-carboxylic acid methyl ester (CAS 1261633-95-7)
- 2-(5-Fluoro-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)acetic acid (CAS 1261771-56-5)
- 2-(5-Fluoro-2'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)acetic acid (CAS 1261787-40-9)
Recommended Standards
- 3'-Fluoro-4'-methyl-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261972-04-6)
- Methyl 4-[2-fluoro-3-(trifluoromethyl)phenyl]benzoate (CAS 1365273-05-7)
- 2-FLuoro-3'-(trifluoromethyl)biphenyl-4-carboxylic acid methyl ester (CAS 1261872-12-1)
- {4-[4-Fluoro-3-(trifluoromethyl)phenyl]phenyl}acetic acid (CAS 1375068-91-9)
- (R)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2,2'-naphthol (CAS 618854-91-4)
- 4-tert-Butyl-N-{2-[4-(4-tert-butylbenzoyl)piperazin-1-yl]ethyl}benzamide hydrochloride (CAS 1033846-80-8)
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