2-Chloro-4-(trifluoromethyl)thiazol-5-amine CAS 136538-99-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-4-(trifluoromethyl)thiazol-5-amine.

2-Chloro-4-(trifluoromethyl)thiazol-5-amine (CAS 136538-99-3), molecular formula C4H2ClF3N2S and molecular weight 202.59 g/mol, is a CATO reference standard with documented purity and traceability.

Structurally, 2-Chloro-4-(trifluoromethyl)thiazol-5-amine (C4H2ClF3N2S) contains a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 202.59 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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