Ramelteon impurity 46 CAS 1365920-11-1
| CAS No. | 1365920-11-1 |
| Molecular Formula | C16H19NO2 |
| Molecular Weight | 257.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Ramelteon impurity 46 (CAS 1365920-11-1, C16H19NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ramelteon impurity 46 (C16H19NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Ramelteon impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19NO2 |
| Molecular Weight | 257.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Related Ramelteon Standards
- Ramelteon Impurity 23 (CAS 196597-30-5)
- Ramelteon Impurity 30 (CAS CATO-C4X-262230)
- Ramelteon Impurity 5 (CAS 880152-62-5)
- Ramelteon Impurity 63 (CAS CATO-C4X-262263)
- Ramelteon Impurity 64 (CAS 1252018-55-5)
- Ramelteon Impurity 65 (CAS 2819252-94-1)
- Ramelteon Impurity N13 (CAS 882434-87-9)
- Ramelteon (CAS 196597-26-9)
Recommended Standards
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