2-Fluoro-5-methyl-1-nitro-3-(trifluoromethyl)benzene CAS 1365988-07-3
| CAS No. | 1365988-07-3 |
| Molecular Formula | C8H5F4NO2 |
| Molecular Weight | 223.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Fluoro-5-methyl-1-nitro-3-(trifluoromethyl)benzene (C8H5F4NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2-Fluoro-5-methyl-1-nitro-3-(trifluoromethyl)benzene (CAS 1365988-07-3) is a high-purity analytical reference standard with the molecular formula C8H5F4NO2 and a molecular weight of 223.12 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Fluoro-5-methyl-1-nitro-3-(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F4NO2 |
| Molecular Weight | 223.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 5-Fluoro-2-(trifluoromethoxy)benzamide (CAS 1092460-85-9)
- 2-Fluoro-3-(trifluoromethoxy)benzamide (CAS 1159512-63-6)
- 4-Fluoro-3-(trifluoromethoxy)benzamide (CAS 1206593-25-0)
- 3-Fluoro-5-(trifluoromethyl)pyridine-2-acetic acid (CAS 1214323-46-2)
- 5-Fluoro-3-(trifluoromethyl)pyridine-2-acetic acid (CAS 1214352-90-5)
- 5-Fluoro-6-(trifluoromethyl)pyridine-2-acetic acid (CAS 1214362-15-8)
- 3-Fluoro-6-(trifluoromethyl)pyridine-2-acetic acid (CAS 1214386-87-4)
- 2-Fluoro-6-(trifluoromethyl)pyridine-4-acetic acid (CAS 1227513-60-1)
Recommended Standards
- 3-Fluoro-5-(trifluoromethoxy)benzamide (CAS 1352999-12-2)
- 2-Amino-5-fluoro-4-(trifluoromethyl)benzoic acid (CAS 1427084-28-3)
- 4-Fluoro-2-(trifluoromethoxy)benzamide (CAS 1323966-41-1)
- Methyl 3-fluoro-6-(trifluoromethyl)picolinate (CAS 1446509-52-9)
- N-Boc-3-methyl-4-piperidinecarboxylic Acid (CAS 512822-50-3)
- 6-Methyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-3-amine (CAS 1000340-22-6)
- 3-(Nitromethyl)-3-oxetanol (CAS 1419518-51-6)
- Methyl 3-(2-(methylsulfonamido)phenoxy)thiophene-2-carboxylate (CAS 900018-87-3)
- (1-Ethyl-5-methyl-1h-pyrazol-4-yl)methanamine (CAS 898046-26-9)
- 2-(3-Tetrahydrofuryl)cyclohexanone (CAS 31891-67-5)
- 1-(4-fluoro-3-nitrophenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 926224-15-9)
- Triethyl 3-Bromopropane-1,1,1-tricarboxylate (CAS 71170-82-6)
- Ethyl 3-bromo-2,6-dimethoxybenzoate (CAS 1352206-56-4)
- Bax inhibitor peptide V5 (CAS 579492-81-2)
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