2-(2,2,2-Trifluoroethyl)-1H-imidazole hydrochloride CAS 1368052-94-1
| CAS No. | 1368052-94-1 |
| Molecular Formula | C5H5F3N2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(2,2,2-Trifluoroethyl)-1H-imidazole hydrochloride (CAS 1368052-94-1), molecular formula C5H5F3N2HCl and molecular weight 186.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(2,2,2-Trifluoroethyl)-1H-imidazole hydrochloride (C5H5F3N2HCl) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(2,2,2-Trifluoroethyl)-1H-imidazole hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5F3N2 HCl |
| Molecular Weight | 186.56 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Trifluoroethyl Standards
- 2,2,2-trifluoroethyl 4-cyanophenylcarbamate (CAS 1000932-40-0)
- 5-(2,2,2-Trifluoroethyl)-1H-pyrazol-3-amine (CAS 1001354-48-8)
- 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid (CAS 1006340-71-1)
- 3-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-amine (CAS 1006448-59-4)
- Methyl 1-(2,2,2-trifluoroethyl)-1h-pyrazole-4-carboxylate (CAS 1006461-60-4)
- 3-Methyl-1-(2,2,2-trifluoroethyl)-1h-pyrazole-4-carbaldehyde (CAS 1006471-12-0)
- Ethyl 1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate (CAS 1006486-11-8)
- 5-Methyl-1-(2,2,2-trifluoroethyl)-1h-pyrazole-3-carboxylic acid (CAS 1006486-45-8)
Recommended Standards
- Ethyl 2-(4-(3,3-dimethylureido)cyclohexyl)acetate (CAS 2410736-56-8)
- 5-(3-Chloro-2-fluorophenyl)nicotinonitrile (CAS 1346692-05-4)
- 1-(2-Chloro-5-methoxy-1H-indol-3-yl)ethanone (CAS 1310318-93-4)
- 4-(Difluoromethyl)-5-hydroxy-6-iodonicotinaldehyde (CAS 1805453-19-3)
- Bis-Clindamycinyl Phosphate (CAS CATO-C4X-134128)
- 4-Amino-2-(difluoromethyl)-6-methoxynicotinonitrile (CAS 1806835-72-2)
- 5-Methoxy-1,3-benzothiazol-2-amine (CAS 54346-87-1)
- 6-(4,5-Dihydro-1H-imidazol-2-yl)-2-(4-(4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy)phenyl)-1H-indole (CAS 73819-48-4)
- Silane, dichlorodimethyl-, polymer with tetrachlorosilane (CAS 51290-26-7)
- Neuropeptide S (human) (CAS 412938-67-1)
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