Methyl 5-fluoro-6-methoxy-1H-indole-2-carboxylate CAS 136818-64-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 5-fluoro-6-methoxy-1H-indole-2-carboxylate.

Methyl 5-fluoro-6-methoxy-1H-indole-2-carboxylate (CAS 136818-64-9), molecular formula C11H10FNO3 and molecular weight 223.20 g/mol, is a CATO reference standard with documented purity and traceability.

Methyl 5-fluoro-6-methoxy-1H-indole-2-carboxylate (C11H10FNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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