4-(Cyclopropylmethyl)-1,2-difluorobenzene CAS 1369849-64-8
| CAS No. | 1369849-64-8 |
| Molecular Formula | C10H10F2 |
| Molecular Weight | 168.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Cyclopropylmethyl)-1,2-difluorobenzene.
4-(Cyclopropylmethyl)-1,2-difluorobenzene (CAS 1369849-64-8) is a high-purity analytical reference standard with the molecular formula C10H10F2 and a molecular weight of 168.18 g/mol.
The molecular framework of 4-(Cyclopropylmethyl)-1,2-difluorobenzene (C10H10F2) is characterized by fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10F2 |
| Molecular Weight | 168.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Cyclopropylmethyl Standards
- 5-(Cyclopropylmethyl)-1,2,4-oxadiazole-3-carboxylic acid (CAS 1342601-92-6)
- 1-(Cyclopropylmethyl)cyclopentane-1-carboxylic acid (CAS 1261269-54-8)
- (S)-1-(Cyclopropylmethyl)pyrrolidine-2-carboxamide (CAS 114812-44-1)
- 1-(Cyclopropylmethyl)piperidine-4-methanamine (CAS 1017400-92-8)
- n-(Cyclopropylmethyl)-1-methylpiperidin-4-amine (CAS 1019506-96-7)
- (Cyclopropylmethyl)(methyl)(pyrrolidin-3-ylmethyl)amine (CAS 1249622-45-4)
- [1-(cyclopropylmethyl)piperidin-3-yl]methanamine (CAS 875270-02-3)
- N-(Cyclopropylmethyl)-2-(pyrrolidin-1-yl)ethanamine (CAS 741698-54-4)
Recommended Standards
- 7-Aminothiazolo[4,5-d]pyrimidin-2(3H)-one (CAS 122970-56-3)
- 1-thien-2-yl-1,4-dihydro-5H-tetrazol-5-one (CAS 141946-05-6)
- (Cyclopropyldifluoromethyl)benzene (CAS 1204296-06-9)
- 6-sulfanylidene-1H,2H,3H,6H,7H-pyrazolo[3,4-d]pyrimidin-3-one (CAS 161715-40-8)
- n-(4-Methylpiperidin-3-yl)pivalamide (CAS 1405747-18-3)
- 5,6-Dichloro-2-(2-chloropyridin-3-yl)-1-(3-fluorobenzyl)-1H-benzo[d]imidazole (CAS 338774-12-2)
- 6-(4-methoxyphenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one (CAS 225385-22-8)
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