4-Amino-6-bromonicotinonitrile CAS 1369851-48-8
| CAS No. | 1369851-48-8 |
| Molecular Formula | C6H4BrN3 |
| Molecular Weight | 198.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 198.02 g/mol gives 4-Amino-6-bromonicotinonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Amino-6-bromonicotinonitrile (CAS 1369851-48-8) is a high-purity analytical reference standard with the molecular formula C6H4BrN3 and a molecular weight of 198.02 g/mol.
4-Amino-6-bromonicotinonitrile (C6H4BrN3) contains a nitrile group, bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4BrN3 |
| Molecular Weight | 198.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- 2-Amino-4-bromonicotinonitrile (CAS 1152617-15-6)
- 2-Amino-6-bromoisonicotinonitrile (CAS 1186194-69-3)
- 4-Amino-5-bromopyridine-2-carbonitrile (CAS 1234616-76-2)
- 5-Amino-6-bromonicotinonitrile (CAS 1260666-04-3)
- 6-Amino-5-bromo-pyridine-2-carbonitrile (CAS 1314974-91-8)
- 5-Amino-2-bromo-pyridine-4-carbonitrile (CAS 1384080-97-0)
- 4-Amino-5-bromonicotinonitrile (CAS 1628557-07-2)
- 5-Amino-2-bromonicotinonitrile (CAS 1706455-42-6)
Recommended Standards
- 5-Bromoimidazo[1,2-c]pyrimidine (CAS 1369157-70-9)
- 7-Bromoimidazo[1,5-b]pyridazine (CAS 1367827-99-3)
- 6-Bromobenzo[c]isoxazole (CAS 139557-44-1)
- 4-Bromo-[1,2,3]triazolo[1,5-a]pyridine (CAS 1367827-91-5)
- 1-Ethylpyrazole-4-carboxylic Acid (CAS 400858-54-0)
- N,N'-((3aR,4R,7R,7aS)-2,2-dimethyl-5-(trimethylsilyl)-3a,4,7,7a-tetrahydrobenzo[d][1,3]dioxole-4,7-diyl)dibenzamide (CAS 1998128-25-8)
- (S)-3,3-difluoro-4-methoxypiperidine (CAS 2306244-93-7)
- 4-(3,5-Dimethoxyphenyl)-2-methyl-1-butene (CAS 951891-51-3)
- tert-Butyl 1-oxa-6-azaspiro[3.4]octane-6-carboxylate (CAS 1264635-65-5)
- 1-(2',4'-Bis(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-5-methyl-1H-pyrazole-3-carboxamide (CAS 784140-68-7)
- 4-((2-Methylbut-3-yn-2-yl)amino)benzoic acid (CAS 1344301-64-9)
- Norepinephrine Impurity 161 (CAS 1215-29-8（free acid）)
- 2,4-Dibromo-6-fluoro-3-(trifluoromethyl)aniline (CAS 1027513-06-9)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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