Oseltamivir Impurity 77 CAS 136994-78-0
| CAS No. | 136994-78-0 |
| Molecular Formula | C12H18O5 |
| Molecular Weight | 242.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Oseltamivir Impurity 77.
As a process- or degradation-related impurity, Oseltamivir Impurity 77 (CAS 136994-78-0, C12H18O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Oseltamivir Impurity 77 (C12H18O5) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Oseltamivir Impurity 77 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H18O5 |
| Molecular Weight | 242.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
Related Oseltamivir Standards
- Oseltamivir Impurity 36 (CAS 212504-90-0)
- Oseltamivir Impurity 241 (CAS CATO-C4X-1720241)
- Oseltamivir Impurity 29 (CAS CATO-C4X-172029)
- Oseltamivir Impurity 85 (CAS CATO-C4X-172085)
- Oseltamivir Impurity 89 (CAS 1234858-94-6)
- Oseltamivir Impurity 38 (CAS CATO-C4X-172038)
- Oseltamivir Impurity 172 (CAS CATO-C4X-1720172)
- Oseltamivir Impurity 132 (CAS 162252-43-9)
Recommended Standards
- Olopatadine Impurity 30 (CAS 728-97-2)
- Ozagrel Impurity 2 (CAS 866157-50-8)
- Imipenem Impurity 12 (CAS CATO-C4X-166212)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
- Phenoxymethylpenicillin Impurity 15 (CAS CATO-C4X-212615)
- Opicapone impurity 19 (CAS CATO-C4X-240419)
- Betamethasone Impurity 108 (CAS CATO-C4X-1437108)
- 1-(Bicyclo[1.1.1]Pentan-1-yl)-1H-pyrazol-4-amine (CAS 2169129-47-7)
- Metamifop (CAS 256412-89-2)
- Alprazolam impurity 23 (CAS CATO-C4X-146023)
- (2S,4R)-1-(tert-Butoxycarbonyl)-4-(2-methylbenzyl)pyrrolidine-2-carboxylic acid (CAS 959578-52-0)
- 3-Methyl-1-(piperidin-1-yl)butan-2-amine dihydrochloride (CAS 148054-89-1)
- (2S,3S)-3-(((tert-Butyldimethylsilyl)oxy)methyl)-2-methyl-1-tosylaziridine-2-carbaldehyde (CAS 2306050-76-8)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
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