4-Chloro-3-methoxyaniline CAS 13726-14-2
| CAS No. | 13726-14-2 |
| Molecular Formula | C7H8ClNO |
| Molecular Weight | 157.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-3-methoxyaniline.
4-Chloro-3-methoxyaniline (CAS 13726-14-2) is a high-purity analytical reference standard with the molecular formula C7H8ClNO and a molecular weight of 157.60 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 4-Chloro-3-methoxyaniline is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 157.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-3-methoxyaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8ClNO |
| Molecular Weight | 157.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-N2-methylpyridine-2,3-diamine (CAS 100114-37-2)
- 4-Chloro-3-ethoxypyridine (CAS 1003711-81-6)
- 5-Chloro-2,3-dimethylpyridine 1-oxide (CAS 1015057-46-1)
- 2-Chloro-5-(methoxymethyl)pyridine (CAS 1016534-59-0)
- 3-Chloro-5-methoxyaniline (CAS 10272-06-7)
- 3-Chloro-5-(methylamino)phenol (CAS 1082113-30-1)
- (6-Chloro-2-methylpyridin-3-yl)methanol (CAS 1093879-95-8)
- 2-Chloro-4-methoxy-5-methylpyridine (CAS 1122090-84-9)
Recommended Standards
- 5-Chloro-2-methoxyaniline (CAS 95-03-4)
- 5-Amino-4-chloro-2-methylphenol (CAS 110102-86-8)
- 3-Amino-2-Chlor-6-Methylphenol (CAS 84540-50-1)
- 3-Chloro-4-Methoxyaniline (CAS 5345-54-0)
- Butanedioic acid, 2-methylene-, 1,4-di-2-propen-1-yl ester (CAS 2767-99-9)
- 4-(4-Bromo-3-methoxybenzyl)morpholine (CAS 1394291-37-2)
- 4-{[(4-chlorophenyl)methyl]sulfanyl}-5-methoxy-2-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)pyrimidine (CAS 478042-71-6)
- 2,5-Bis(trifluoromethyl)benzothioamide (CAS 1186194-57-9)
- Ethyl 4-(((benzyloxy)carbonyl)amino)-3-hydroxy-1-methyl-1H-pyrrole-2-carboxylate (CAS 212184-25-3)
- 1-ethyl-4-hydroxycyclohexane-1-carboxylic acid (CAS 1509096-29-0)
- 3-Chloro-5-cyclopropoxy-2-isopropoxypyridine (CAS 1243289-56-6)
- 3,6-Diethynylcarbazole (CAS 909342-65-0)
- 5-Azaspiro[2.5]octan-8-ol (CAS 955028-96-3)
- Semaglutide Impurity 133 (CAS CATO-C4X-2226133)
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