5-Chloro-10-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione CAS 137347-70-7
| CAS No. | 137347-70-7 |
| Molecular Formula | C12H18ClN3O2 |
| Molecular Weight | 271.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 271.74 g/mol gives 5-Chloro-10-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Chloro-10-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (CAS 137347-70-7) is a high-purity analytical reference standard with the molecular formula C12H18ClN3O2 and a molecular weight of 271.74 g/mol.
The molecular framework of 5-Chloro-10-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (C12H18ClN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H18ClN3O2 |
| Molecular Weight | 271.74 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- Methyl 3-((6-(tert-butyl)-2-chloropyrimidin-4-yl)amino)propanoate (CAS 1373423-14-3)
- (S)-tert-Butyl (1-(3-chlorophenyl)-2-hydroxyethyl)carbamate (CAS 1379546-46-9)
- 2-chloro-N-[1-(4,5-dimethoxy-2-methylphenyl)ethyl]acetamide (CAS 1311314-77-8)
- (S)-1-(4-chloro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethan-1-amine (CAS 1393176-11-8)
- 2-Butyl-5-methyl-3-phenylfuran (CAS 147328-19-6)
- N-(5-Benzoyl-6-methyl-2-oxo-2H-pyran-3-yl)-4-methoxybenzamide (CAS 338404-96-9)
- 2-Methylbenzo[d]thiazol-5-ol (CAS 68867-14-1)
- Rivaroxaban Impurity 30 (CAS 2204368-63-6)
- 2-Oxospiro[3.5]Nonane-7-carboxylic acid (CAS 2167815-01-0)
- 5-(1-Aminobutyl)-2-fluorophenol (CAS 1270557-92-0)
- Ethyl 3-(indolin-1-yl)propanoate (CAS 887574-27-8)
- 2-Chloro-n-({3-[(propan-2-yloxy)methyl]phenyl}methyl)acetamide (CAS 1311314-65-4)
- cyclohexyl 4-(4-methylpiperazinomethyl)phenyl ketone (CAS 898763-60-5)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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