Tert-butyl 4,4-difluoro-3-formylpiperidine-1-carboxylate CAS 1373503-71-9
| CAS No. | 1373503-71-9 |
| Molecular Formula | C11H17F2NO3 |
| Molecular Weight | 249.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Tert-butyl 4,4-difluoro-3-formylpiperidine-1-carboxylate (C11H17F2NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Tert-butyl 4,4-difluoro-3-formylpiperidine-1-carboxylate (CAS 1373503-71-9) is a high-purity analytical reference standard with the molecular formula C11H17F2NO3 and a molecular weight of 249.25 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H17F2NO3 |
| Molecular Weight | 249.25 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 1-Boc-3,3-difluoropiperidine-4-carbaldehyde (CAS 1373503-65-1)
- Tert-butyl 3,3-difluoro-5-formylpiperidine-1-carboxylate (CAS 1374655-95-4)
- Tert-butyl 2-acetyl-4,4-difluoropyrrolidine-1-carboxylate (CAS 1334486-72-4)
- 1-(2-Sulfamidoethyl)-2-methyl-5-nitroimidazole (CAS 1383370-92-0)
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