2-Fluoro-5-methoxy-3-(trifluoromethyl)-benzoyl chloride CAS 1373920-78-5
| CAS No. | 1373920-78-5 |
| Molecular Formula | C9H5ClF4O2 |
| Molecular Weight | 256.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Fluoro-5-methoxy-3-(trifluoromethyl)-benzoyl chloride.
2-Fluoro-5-methoxy-3-(trifluoromethyl)-benzoyl chloride (CAS 1373920-78-5) is a high-purity analytical reference standard with the molecular formula C9H5ClF4O2 and a molecular weight of 256.58 g/mol.
Based on its molecular formula C9H5ClF4O2, 2-Fluoro-5-methoxy-3-(trifluoromethyl)-benzoyl chloride contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 256.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H5ClF4O2 |
| Molecular Weight | 256.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
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Recommended Standards
- 5-Chloro-2-nitro-4-(trifluoromethoxy)aniline (CAS 914637-23-3)
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- 1-(3-Bromobenzoyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid (CAS 1373246-96-8)
- 2-Amino-4-fluoro-6-methoxy-5-(trifluoromethyl)pyrimidine (CAS 92983-84-1)
- S-(5-(Pyrazin-2-yl)-1,3,4-oxadiazol-2-yl) ethanethioate (CAS 104820-26-0)
- Benzene, 1-bromo-4-(hexylsulfonyl)- (CAS 856165-22-5)
- 2-(4-(Benzyloxy)-1,2,5-oxadiazol-3-yl)acetic acid (CAS 1226869-84-6)
- (R)-[(1-Phenylethyl)amino]acetic Acid (CAS 78397-15-6)
- 3-(Difluoromethyl)-4-(trifluoromethyl)pyridine-2,6-diamine (CAS 1805234-98-3)
- 2-(6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetic acid (CAS 68254-80-8)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
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