5-Chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine CAS 1374829-40-9
| CAS No. | 1374829-40-9 |
| Molecular Formula | C8H12ClN3O |
| Molecular Weight | 201.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-Chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine (CAS 1374829-40-9), molecular formula C8H12ClN3O and molecular weight 201.65 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine (C8H12ClN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 5-Chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12ClN3O |
| Molecular Weight | 201.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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