1,1,1-Trifluoro-3-(1H-indol-3-yl)propan-2-amine CAS 137496-38-9
| CAS No. | 137496-38-9 |
| Molecular Formula | C11H11F3N2 |
| Molecular Weight | 228.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 1,1,1-Trifluoro-3-(1H-indol-3-yl)propan-2-amine (CAS 137496-38-9), a certified reference material (molecular formula C11H11F3N2, MW 228.21 g/mol) for analytical method development and quality control.
The molecular framework of 1,1,1-Trifluoro-3-(1H-indol-3-yl)propan-2-amine (C11H11F3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11F3N2 |
| Molecular Weight | 228.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoro Standards
- (1S)-2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)ethan-1-amine (CAS 1270095-40-3)
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- 3,3,3-trifluoro-2-(1H-indol-3-yl)propan-1-amine (CAS 936493-21-9)
- 3,3,3-Trifluoro-(2-tetrahydrothienylmethyl)propionic acid (CAS 480438-83-3)
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- 1,1,1-Trifluoro-4-(4-methoxyphenyl)but-3-yn-2-one (CAS 89965-74-2)
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