2-Isopropyl-6-(trifluoromethyl)morpholin-3-one CAS 1375472-22-2
| CAS No. | 1375472-22-2 |
| Molecular Formula | C8H12F3NO2 |
| Molecular Weight | 211.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Isopropyl-6-(trifluoromethyl)morpholin-3-one (CAS 1375472-22-2), molecular formula C8H12F3NO2 and molecular weight 211.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Isopropyl-6-(trifluoromethyl)morpholin-3-one (C8H12F3NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-Isopropyl-6-(trifluoromethyl)morpholin-3-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12F3NO2 |
| Molecular Weight | 211.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Isopropyl Standards
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- 1-Butyl-5-isopropyl-1h-1,2,3-triazole-4-carboxylic acid (CAS 1249357-39-8)
- 1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-ol (CAS 832714-37-1)
- (6-Isopropyl-2-methylimidazo[2,1-b][1,3,4]thiadiazol-5-yl)methanol (CAS 1267798-65-1)
- 5-Isopropyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid (CAS 1400635-79-1)
- 9-Isopropyl-9-azabicyclo[3.3.1]nonane-3-carboxylic acid (CAS 1209931-29-2)
- 2-Isopropyl-[1,1'-biphenyl]-4-amine (CAS 1324003-75-9)
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Recommended Standards
- 6-Methyl-3-(trifluoromethyl)quinoline (CAS 1360782-94-0)
- 9-(Trifluoromethyl)-3-oxa-7-azabicyclo[3.3.1]nonan-9-ol (CAS 1375473-70-3)
- 1-Amino-4-(trifluoromethyl)cyclohexane-1-carboxylic acid (CAS 1344110-31-1)
- N-(4-Methoxy-2-(nitro)phenyl)acetamide (CAS 1391052-34-8)
- n-(3-(1h-Imidazol-1-yl)propyl)-4-chlorobenzamide (CAS 93669-24-0)
- Isovaleric Acid-d9 (CAS 344298-81-3)
- 9A-phenylhexahydro-1H-pyrido[1,2-a]pyrimidin-6(2H)-one (CAS 6029-43-2)
- 5-Aminovaleric Acid (CAS 660-88-8)
- Iguratimod impurity 92 (CAS CATO-C4X-182692)
- 3-Nitro-4-(thiazolidin-3-yl)benzaldehyde (CAS 1774893-95-6)
- ethyl 4-(dimethylamino)-3-oxobutanoate hydrochloride (CAS 134020-71-6)
- 2-(1-Methyl-1H-imidazol-4-yl)ethanamine bis(4-methylbenzenesulfonate) (CAS 921203-30-7)
- R428 (CAS 1037624-75-1)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
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