2-(Ethylsulfonyl)-1-fluoro-4-nitrobenzene CAS 1375473-74-7
| CAS No. | 1375473-74-7 |
| Molecular Formula | C8H8FNO4S |
| Molecular Weight | 233.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Ethylsulfonyl)-1-fluoro-4-nitrobenzene (C8H8FNO4S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
2-(Ethylsulfonyl)-1-fluoro-4-nitrobenzene (CAS 1375473-74-7) is a high-purity analytical reference standard with the molecular formula C8H8FNO4S and a molecular weight of 233.22 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8FNO4S |
| Molecular Weight | 233.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Ethylsulfonyl Standards
- 4-(Ethylsulfonyl)-1-fluoro-2-nitrobenzene (CAS 1132754-31-4)
- Ethyl 5-(ethylsulfonyl)isoxazole-3-carboxylate (CAS 1707667-67-1)
- 5-((Ethylsulfonyl)methyl)-1-methyl-4-nitro-1H-pyrazole (CAS 1710293-68-7)
- 3-(1-(Ethylsulfonyl)ethyl)-4-methylpyrrolidine-2,5-dione (CAS 58467-34-8)
- 1-(1-(Ethylsulfonyl)azetidin-3-yl)piperazine (CAS 1495720-37-0)
- 3-(Ethylsulfonyl)propane-1-sulfonyl chloride (CAS 1490041-20-7)
- 1-(2-(Ethylsulfonyl)ethyl)-3,5-dimethyl-1h-pyrazol-4-amine (CAS 1157828-83-5)
- 1-(3-(Ethylsulfonyl)propyl)-4-methyl-1h-pyrazol-3-amine (CAS 1491709-01-3)
Recommended Standards
- 1-Acetyl-7-hydroxy-6-methoxy-1H-indole-4-carbaldehyde (CAS 137542-66-6)
- 5-(2,5-Dihydro-1h-pyrrol-1-yl)isophthalic acid (CAS 1378683-16-9)
- 2-Fluoro-5-(methylsulfonamido)benzoic acid (CAS 137315-01-6)
- 2-(Ethoxycarbonyl)indole-5-carboxylic Acid (CAS 138731-14-3)
- 2-Acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl Azide (CAS 214467-60-4)
- CAS 287111-05-1 (CAS 287111-05-1)
- (1,2-Dichlorotrifluoroethyl)cyclohexane (CAS 219904-95-7)
- 7-(7-aminoheptanamido)heptanoic acid hydrochloride (CAS 1423034-53-0)
- hex-5-ene-1,2-diamine dihydrochloride (CAS 1384428-80-1)
- 1-(5-Fluoro-1H-indol-3-yl)-N,N-dimethylmethanamine (CAS 343-90-8)
- 8-Ethyl-4-hydrazinyl-2-methylquinoline hydrochloride (CAS 1172882-67-5)
- 2-(1,2-oxazol-5-yl)pyridine (CAS 1314809-76-1)
- Ethyl 3-Oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (CAS 7251-53-8)
- Tirzepatide Impurity 49 (CAS CATO-C4X-324049)
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