3-(difluoromethyl)pyrrolidine hydrochloride CAS 1376176-56-5
| CAS No. | 1376176-56-5 |
| Molecular Formula | C5H9F2N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(difluoromethyl)pyrrolidine hydrochloride is closely related to fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(difluoromethyl)pyrrolidine hydrochloride (CAS 1376176-56-5) is a high-purity analytical reference standard with the molecular formula C5H9F2NHCl and a molecular weight of 157.59 g/mol.
3-(difluoromethyl)pyrrolidine hydrochloride (C5H9F2NHCl) contains fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(difluoromethyl)pyrrolidine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H9F2N HCl |
| Molecular Weight | 157.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related difluoromethyl Standards
- 2-(2-(Difluoromethyl)phenyl)acetic acid (CAS 1000517-62-3)
- 2-[4-(difluoromethyl)phenyl]acetic acid (CAS 1000524-74-2)
- 2-(4-(Difluoromethyl)phenyl)acetonitrile (CAS 1000529-64-5)
- 2-(3-(Difluoromethyl)phenyl)acetonitrile (CAS 1000529-78-1)
- 2-(4-(Difluoromethyl)phenyl)ethan-1-amine (CAS 1000539-08-1)
- 2-(3-(Difluoromethyl)phenyl)acetic acid (CAS 1000547-15-8)
- 2-(2-(Difluoromethyl)phenyl)acetonitrile (CAS 1000556-48-8)
- 2-(2-(Difluoromethyl)phenyl)ethanamine (CAS 1000559-85-2)
Recommended Standards
- methyl 3-amino-3-(2-fluorophenyl)butanoate (CAS 1511048-32-0)
- 1-(2-Bromophenyl)-3-phenyl-1H-pyrazol-5-amine (CAS 890764-12-2)
- Ethyl 2-(4-methoxyphenylcarbonothioylthio)acetate (CAS 129841-40-3)
- 6-Aminobicyclo[2.2.1]heptan-2-ol (CAS 223595-58-2)
- (2-(((tert-Butyldimethylsilyl)oxy)methyl)thiazol-5-yl)boronic acid (CAS 2806011-08-3)
- (2-Isopropoxy-5-methoxy-phenyl)-methanol (CAS 1094903-71-5)
- 4-(Prop-2-yn-1-ylsulfanyl)-2-(pyridin-2-yl)-6-(trifluoromethyl)pyrimidine (CAS 338418-25-0)
- Moronic acid (CAS 6713-27-5)
- 2-(3,4,5-Trimethyl-1H-pyrazol-1-yl)propanehydrazide (CAS 1217862-91-3)
- Semaglutide impurity 202 (CAS CATO-C4X-2226202)
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