Apatinib impurity 4 CAS 1376710-40-5
| CAS No. | 1376710-40-5 |
| Molecular Formula | C24H23N5O2 |
| Molecular Weight | 413.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apatinib impurity 4.
Apatinib impurity 4 (CAS 1376710-40-5) is a certified pharmaceutical impurity reference standard with the molecular formula C24H23N5O2 and a molecular weight of 413.47 g/mol.
Apatinib impurity 4 (C24H23N5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H23N5O2 |
| Molecular Weight | 413.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 5 |
Related Apatinib Standards
Recommended Standards
- Baricitinib Impurity 40 (CAS CATO-C4X-226040)
- Isosulfan Blue Impurity 5 (CAS 2828260-22-4)
- Troxipide Impurity 27 (CAS 30751-15-6)
- Flumethasone-d3 (CAS CATO-CCAD303315)
- Palbociclib impurity 132 (CAS CATO-C4X-1125132)
- Natamycin Impurity 10 (CAS CATO-C4X-204010)
- Pemetrexed Impurity 17 (CAS CATO-C4X-172617)
- N-(1-(2-((4-Fluorophenyl)amino)-2-oxoethyl)-3-oxo-2-phenyl-2,3-dihydro-1H-indazol-5-yl)propionamide (CAS 1251628-60-0)
- 2-Propenamide,3-[3,4-bis(acetyloxy)phenyl]- (CAS 129488-34-2)
- N-ethyl-6-methylpyridazin-3-amine (CAS 1250628-49-9)
- 2'-Chloro-4'-methyl-[1,1'-biphenyl]-4-ol (CAS 194548-52-2)
- 2-(2,3-Dichlorophenyl)-2-hydroxyacetic acid (CAS 35599-91-8)
- Osmium(iv)oxide (CAS 12036-02-1)
- Peptide YY (3-36) (human) (CAS 123583-37-9)
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