4-Bromo-5-chloro-8-methoxyquinoline-3-carboxylic acid CAS 1378259-83-6

Purity 97%+In StockPharmaceutical Standards
CAS No.1378259-83-6
Molecular FormulaC11H7BrClNO3
Molecular Weight316.54 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4-Bromo-5-chloro-8-methoxyquinoline-3-carboxylic acid CAS 1378259-83-6 chemical structure

Description

The occurrence of 4-Bromo-5-chloro-8-methoxyquinoline-3-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

4-Bromo-5-chloro-8-methoxyquinoline-3-carboxylic acid (CAS 1378259-83-6) is a high-purity analytical reference standard with the molecular formula C11H7BrClNO3 and a molecular weight of 316.54 g/mol.

4-Bromo-5-chloro-8-methoxyquinoline-3-carboxylic acid (C11H7BrClNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-Bromo-5-chloro-8-methoxyquinoline-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC11H7BrClNO3
Molecular Weight316.54 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1991
Halogen ContentCl/Br-containing
Nitrogen Atoms1

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