4-methyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)pyridine CAS 1378865-93-0
| CAS No. | 1378865-93-0 |
| Molecular Formula | C10H18F3N |
| Molecular Weight | 209.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-methyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)pyridine.
4-methyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)pyridine (CAS 1378865-93-0) is a high-purity analytical reference standard with the molecular formula C10H18F3N and a molecular weight of 209.25 g/mol.
The molecular framework of 4-methyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)pyridine (C10H18F3N) is characterized by fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H18F3N |
| Molecular Weight | 209.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related methyl Standards
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Recommended Standards
- tert-butyl 2-hydrazinylpyridine-3-carboxylate (CAS 1374849-76-9)
- (S)-N-Methyl-3-cyclohexyl-1,1,1-trifluoropropan-2-amine (CAS 1389310-17-1)
- 2-(p-Tolylamino)isonicotinonitrile (CAS 137225-07-1)
- (R)-N-Methyl-3-cyclohexyl-1,1,1-trifluoropropan-2-amine (CAS 1389310-21-7)
- Methyl 2,4,6-trichloropyrimidine-5-carboxylate (CAS 87846-94-4)
- Methyl 2-[bis(tertbutoxycarbonyl)-amino]thiazole-5-carboxylate (CAS 1311278-00-8)
- 3-(4-Bromophenyl)-1-methylpyrrolidine hydrochloride (CAS 2044705-04-4)
- cis-tert-Butyl 4-hydroxy-2-methylpyrrolidine-1-carboxylate (CAS 2299231-07-3)
- 4,4'-(2,3,5,6-Tetramethyl-1,4-phenylene)dipyridine (CAS 1124218-83-2)
- 1-(3,3-dimethylazetidin-1-yl)cyclopropanecarboxylic acid (CAS 1501023-20-6)
- 5-Bromo-N,N-dimethylthiophene-3-carboxamide (CAS 1147488-26-3)
- 1-(4-(Ethylsulfonyl)-2-nitrophenyl)-4-methylpiperazine hydrochloride (CAS 1170982-65-6)
- 1,5-Diazacycloundecan-2-one (CAS 1824440-20-1)
- Tirzepatide Impurity 45 (CAS CATO-C4X-324045)
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