4-Chloro-2-ethynylphenol CAS 1378976-47-6
| CAS No. | 1378976-47-6 |
| Molecular Formula | C8H5ClO |
| Molecular Weight | 152.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-2-ethynylphenol.
4-Chloro-2-ethynylphenol (CAS 1378976-47-6) is a high-purity analytical reference standard with the molecular formula C8H5ClO and a molecular weight of 152.58 g/mol.
Based on its molecular formula C8H5ClO, 4-Chloro-2-ethynylphenol contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 152.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-ethynylphenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClO |
| Molecular Weight | 152.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 3-Chloro-1H-pyrrolo[3,2-c]pyridine (CAS 1000342-65-3)
- 2-(2-Chloro-4-pyridyl)acetonitrile (CAS 1000565-45-6)
- 2-(2-Chloro-3-pyridyl)acetonitrile (CAS 101012-32-2)
- 4-Chloro-2-cyano-6-methylpyridine, 97% (CAS 104711-65-1)
- Methyl 4-chloro-3-hydroxybutanoate (CAS 10488-68-3)
- 5-Chloro-2-ethynylpyridin-3-amine (CAS 1150617-82-5)
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- 4-Chloro-6-azaindole (CAS 1188313-15-6)
Recommended Standards
- 6-(Chloromethyl)-2-cyanopyridine (CAS 135450-23-6)
- 3-Chloro-1H-pyrrolo[2,3-c]pyridine (CAS 1384079-12-2)
- 4-Chlorophenylcyanamide (CAS 13463-94-0)
- 5-Chloroimidazo[1,5-a]pyridine (CAS 141912-70-1)
- 1-[4-(2-hydroxyethyl)phenyl]hexahydropyrimidine-2,4-dione (CAS 2758531-98-3)
- (R)-(2,3-Dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol (CAS 139290-65-6)
- 1-(2-Methoxyethyl)cyclohexan-1-amine (CAS 1249264-65-0)
- 4-Chloro-6-(thiophen-2-ylthio)pyrimidin-2-amine (CAS 339016-11-4)
- 7-Bromo-2-phenylquinazolin-4(3H)-one (CAS 1152237-10-9)
- 1-(4-Chloro-2,5-difluorophenyl)-4-(5,5-dimethyl-1,3-dioxan-2-yl)butan-1-one (CAS 898757-41-0)
- 4-Bromopentane-2,3-dione (CAS 21619-25-0)
- Gliquidone Impurity 8 (CAS 1133-54-6)
- (1S,3R)-3-(3,4-dimethylbenzoyl)cyclohexane-1-carboxylic acid (CAS 735269-86-0)
- [Tyr0] Fibrinopeptide A, human (CAS 103226-11-5)
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